مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

EFFECTS OF TURMERIC ON HOMOCYSTEINE AND FETUIN-A IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY

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Abstract

 Background: Elevated levels of HOMOCYSTEINE (Hcy) and FETUIN-A are important risk factors for cardiovascular diseases in patients with a NONALCOHOLIC FATTY LIVER disease (NAFLD). There is limited evidence regarding the effects of TURMERIC on NAFLD.Objectives: This study aimed at investigating the effects of TURMERIC supplementation on serum levels of Hcy and FETUIN-A in patients with NAFLD.Methods: In this double-blind, randomized, controlled clinical trial, 46 NAFLD patients (21 males and 25 females; age range, 20 - 60 years) with body mass index ranged 24.9 - 40 kg/m2 were recruited from Sheikh-ol-Raees clinic in Tabriz City, Iran during Nov 2014- May 2015. The participants were allocated into the two groups using the block randomization method. The intervention and control groups received 3g of TURMERIC (n=23) and placebo (n=23), daily for 12 weeks. Fasting blood samples were collected at baseline and at the end of the trial for biochemical analysis.Results: TURMERIC supplementation significantly decreased serum levels of Hcy, compared with the placebo group at the end of the study (by 27.83%, P=0.034). No significant difference was observed between the two groups in serum levels of FETUIN-A after the intervention (P>0.05). Serum levels of glucose, insulin and homeostasis model assessment for insulin resistance were declined significantly in the TURMERIC group (by 1.22%, 17.69% and 19.48%, P=0.039, P=0.013 and P=0.001, respectively) compared to the placebo.Conclusions: TURMERIC consumption had beneficial effects on serum Hcy levels and maybe useful in management of this risk factor in NAFLD patients.

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    APA: Copy

    GHAFFARI, AIDA, RAFRAF, MARYAM, NAVEKAR, ROYA, SEPEHRI, BITA, ASGHARI JAFARABADI, MOHAMMAD, GHAVAMI, SEYED MOSTAFA, & MANAFI, NAHID. (2017). EFFECTS OF TURMERIC ON HOMOCYSTEINE AND FETUIN-A IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(4), 0-0. SID. https://sid.ir/paper/293375/en

    Vancouver: Copy

    GHAFFARI AIDA, RAFRAF MARYAM, NAVEKAR ROYA, SEPEHRI BITA, ASGHARI JAFARABADI MOHAMMAD, GHAVAMI SEYED MOSTAFA, MANAFI NAHID. EFFECTS OF TURMERIC ON HOMOCYSTEINE AND FETUIN-A IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(4):0-0. Available from: https://sid.ir/paper/293375/en

    IEEE: Copy

    AIDA GHAFFARI, MARYAM RAFRAF, ROYA NAVEKAR, BITA SEPEHRI, MOHAMMAD ASGHARI JAFARABADI, SEYED MOSTAFA GHAVAMI, and NAHID MANAFI, “EFFECTS OF TURMERIC ON HOMOCYSTEINE AND FETUIN-A IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED DOUBLE-BLIND PLACEBO-CONTROLLED STUDY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 4, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293375/en

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