EFFECT OF SAFFRON (FAN HONG HUA) ON THE READINESS OF THE UTERINE CERVIX IN TERM PREGNANCY: A PLACEBO-CONTROLLED RANDOMIZED TRIAL

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SADI ROGHAIEH; MOHAMMAD ALIZADEH CHARANDABI SAKINEH; MIRGHAFOURVAND MOJGAN; JAVADZADEH YOUSEF; AHMADI BONABI AFKHAM

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:10 Page(s): 0-0

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Title

EFFECT OF SAFFRON (FAN HONG HUA) ON THE READINESS OF THE UTERINE CERVIX IN TERM PREGNANCY: A PLACEBO-CONTROLLED RANDOMIZED TRIAL

Author(s)

Keywords

SAFFRON

READINESS

CERVIX

TERM PREGNANCY

BISHOP’S SCORE

HERBAL MEDICINE

Abstract

Background: READINESS of the CERVIX is required for successful induction of labor, and there are a number of ways in which this can be achieved.Objectives: The aim of the present study was to assess whether taking SAFFRON orally could have an effect on the cervical READINESS (primary outcome) and some delivery and neonatal outcomes (secondary outcomes) in women in the stage of TERM PREGNANCY.Patients and Methods: In this double-blind trial, 50 women with a gestational age of 39 to 41 weeks, no indication of cesarean section, a BISHOP’S SCORE of less than 4, who had plan to have vaginal delivery at Shohada hospital of Bonab, Iran were randomized into two groups receiving three 250mg SAFFRON or placebo pills in 24 hours. The READINESS of the CERVIX was assessed using the BISHOP’S SCORE. The Mann-Whitney U test was used to compare the scores between the groups.Results: There were no significant differences between the groups in terms of the BISHOP’S SCORE at the baseline (P=0.792) and 10- 12 hours after starting the intervention (P=0.159). The BISHOP’S SCORE was significantly higher in the SAFFRON group 20 - 24 hours after the intervention was started (P=0.029) and just after onset of active uterine contractions (P=0.003). In the SAFFRON group, there was no cesarean section and 1 meconium staining of the fetus, but 3 and 4, respectively, in the placebo group. There was no statistically significant difference between the groups in terms of the timing of the onset of spontaneous active uterine contractions, the duration of the first and second stages of labor, the need for delivery augmentation, and the first and fifth minutes of neonatal Apgar (P>0.05). No adverse event was reported in any of the groups.Conclusions: SAFFRON can increase the READINESS of the CERVIX in term pregnancies. However, the study limitations do not allow for any definite conclusions for its use in clinical practice, and more research is needed to assess its effect on delivery and neonatal outcomes.

Cites

Letter to Editor, Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms

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APA: Copy

SADI, ROGHAIEH, MOHAMMAD ALIZADEH CHARANDABI, SAKINEH, MIRGHAFOURVAND, MOJGAN, JAVADZADEH, YOUSEF, & AHMADI BONABI, AFKHAM. (2016). EFFECT OF SAFFRON (FAN HONG HUA) ON THE READINESS OF THE UTERINE CERVIX IN TERM PREGNANCY: A PLACEBO-CONTROLLED RANDOMIZED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(10), 0-0. SID. https://sid.ir/paper/293442/en

Vancouver: Copy

SADI ROGHAIEH, MOHAMMAD ALIZADEH CHARANDABI SAKINEH, MIRGHAFOURVAND MOJGAN, JAVADZADEH YOUSEF, AHMADI BONABI AFKHAM. EFFECT OF SAFFRON (FAN HONG HUA) ON THE READINESS OF THE UTERINE CERVIX IN TERM PREGNANCY: A PLACEBO-CONTROLLED RANDOMIZED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(10):0-0. Available from: https://sid.ir/paper/293442/en

IEEE: Copy

ROGHAIEH SADI, SAKINEH MOHAMMAD ALIZADEH CHARANDABI, MOJGAN MIRGHAFOURVAND, YOUSEF JAVADZADEH, and AFKHAM AHMADI BONABI, “EFFECT OF SAFFRON (FAN HONG HUA) ON THE READINESS OF THE UTERINE CERVIX IN TERM PREGNANCY: A PLACEBO-CONTROLLED RANDOMIZED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 10, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293442/en

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