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Information Journal Paper

Title

THE EFFECTS OF MONOSODIUM GLUTAMATE AND TANNIC ACID ON ADULT RATS

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  0-0

Abstract

 Background: MONOSODIUM GLUTAMATE (MSG) is a widely-used flavor enhancer and stabilizer in ready-made or packaged foods. The excessive use of MSG has been shown to increase OXIDATIVE STRESS in different organ systems and causes glucose metabolism disorders, obesity, and coronary diseases.Objectives: In this study, the ANTIOXIDANT activity of TANNIC ACID was investigated experimentally with respect to its protective effects against overdosed MSG-induced OXIDATIVE STRESS in rats. The study took place in Turkey in August 2013.Methods: Four groups (n=7) of three- to four-month-old Sprague-Dawley female rats were used in this study. The first group was the control, who were administered saline. The second group received TANNIC ACID (50 mg/kg, 3 days) intraperitoneally (i.p.). The third group received MSG (2 g/kg, 7 days) i.p., and the fourth group received both TANNIC ACID (50 mg/kg, 3 days, pretreatment) and MSG (2 g/kg, 7 days) i.p. The animals were euthanized ten days later. Blood was collected for determining the hematological values and blood glucose levels. Superoxide dismutase (SOD) and malondialdehyde (MDA) levels were determined in the brain, liver, andkidney homogenates, and in the erythrocyte hemolysate. Histopathological examination of the brain, liver, and kidneys was conducted through hematoxylin-eosin staining.Results: The data showed that the TANNIC ACID treatment statistically decreased the MDA levels in the brain tissues of the group administered MSG and TANNIC ACID (P<0.001) when compared to the corresponding values of the control group. The SOD activities in the blood hemolysates of the MSG and TANNIC ACID group increased when compared to the corresponding values for the MSG group (P<0.01). Additionally, we found that pretreatment with TANNIC ACID reduced blood glucose levels in comparison to the levels of the MSG group (P=0.029). The results of our study show that TANNIC ACID pretreatment in adult rats decreased blood glucose levels and OXIDATIVE STRESS.Conclusions: In the literature, it was observed that short-term MSG exposure does not cause significant histological changes in the kidneys, liver, or brain cortex. These findings should be re-evaluated in additional long-term studies.

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    APA: Copy

    UGUR CALIS, IBRAHIM, COSAN, DIDEM TURGUT, SAYDAM, FARUK, KOLAC, UMUT KEREM, SOYOCAK, AHU, KURT, HULYAM, VEYSI GUNES, HASAN, SAHINTURK, VAROL, MUTLU, FEZAN SAHIN, OZDEMIR KOROGLU, ZEYNEP, & DEGIRMENCI, IRFAN. (2016). THE EFFECTS OF MONOSODIUM GLUTAMATE AND TANNIC ACID ON ADULT RATS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(10), 0-0. SID. https://sid.ir/paper/293445/en

    Vancouver: Copy

    UGUR CALIS IBRAHIM, COSAN DIDEM TURGUT, SAYDAM FARUK, KOLAC UMUT KEREM, SOYOCAK AHU, KURT HULYAM, VEYSI GUNES HASAN, SAHINTURK VAROL, MUTLU FEZAN SAHIN, OZDEMIR KOROGLU ZEYNEP, DEGIRMENCI IRFAN. THE EFFECTS OF MONOSODIUM GLUTAMATE AND TANNIC ACID ON ADULT RATS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(10):0-0. Available from: https://sid.ir/paper/293445/en

    IEEE: Copy

    IBRAHIM UGUR CALIS, DIDEM TURGUT COSAN, FARUK SAYDAM, UMUT KEREM KOLAC, AHU SOYOCAK, HULYAM KURT, HASAN VEYSI GUNES, VAROL SAHINTURK, FEZAN SAHIN MUTLU, ZEYNEP OZDEMIR KOROGLU, and IRFAN DEGIRMENCI, “THE EFFECTS OF MONOSODIUM GLUTAMATE AND TANNIC ACID ON ADULT RATS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 10, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293445/en

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