ACCELERATED BURN WOUND CLOSURE IN MICE WITH A NEW FORMULA BASED ON TRADITIONAL MEDICINE

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MEHRABANI MEHRNAZ; SEYYEDKAZEMI SEYYED MOHSEN; NEMATOLLAHI MOHAMMAD HADI; JAFARI ELHAM; MEHRABANI MITRA; MEHDIPOUR MOHAMMAD; SHEIKHSHOAEE ZAHRA; MANDEGARY ALI

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Journal: Iranian Red Crescent Medical Journal Year:2016 | Volume:18 | Issue:11 Page(s): 0-0

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Title

ACCELERATED BURN WOUND CLOSURE IN MICE WITH A NEW FORMULA BASED ON TRADITIONAL MEDICINE

Author(s)

Keywords

BURN

FOLK MEDICINE

HEALING

Abstract

Background: A combination of the oils of sesame, hemp, wild pistachio, and walnut has been used for treatment of skin disorders, including wound BURNs, in some parts of Kerman, Iran. Evaluation of this remedy in the form of a pharmaceutical formulation in animal models can pave the way for its future application in wound BURN HEALING in humans.Objectives: This experimental study investigated the HEALING potential of a new formula (NF) based on FOLK MEDICINE from Iran for the treatment of third degree BURNs in mice. The formula was a combination of the oils of four plants: sesame (Sesamum indicum L.), wild pistachio (Pistacia atlantica Desf.), hemp (Cannabis sativa L.), and walnut (Juglans regia L.) Methods: Twenty-four mice were selected based on simple random sampling. Twenty-five percent of the total body surface area was BURNed by exposure to boiling water, according to the Walker-Mason method. NF and silver sulfadiazine (the positive control) were applied topically twice a day for 21 days. The BURNed area in the negative control group was left untreated. Epithelialization time and the percent of wound contraction were measured during the treatment period. The process of wound repairing was evaluated using histological (H and E and trichrome staining) and immunohistological (anti-pancytokeratin) methods.Results: When compared to the controls, NF significantly improve dwoundcontraction after day 10. Epithelialization time in the NF group was significantly faster than in the other groups (20 vs.25.5 days) (P<0.001). Histopathological and immunohistochemical findings confirmed the efficacy of the NF.Conclusions: A new therapeutic remedy was introduced for the treatment of BURN wounds. Further clinical and molecular studies are suggested to determine the exact mechanism (s) involved in the BURN wound HEALING effect of NF.

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APA: Copy

MEHRABANI, MEHRNAZ, SEYYEDKAZEMI, SEYYED MOHSEN, NEMATOLLAHI, MOHAMMAD HADI, JAFARI, ELHAM, MEHRABANI, MITRA, MEHDIPOUR, MOHAMMAD, SHEIKHSHOAEE, ZAHRA, & MANDEGARY, ALI. (2016). ACCELERATED BURN WOUND CLOSURE IN MICE WITH A NEW FORMULA BASED ON TRADITIONAL MEDICINE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 18(11), 0-0. SID. https://sid.ir/paper/293457/en

Vancouver: Copy

MEHRABANI MEHRNAZ, SEYYEDKAZEMI SEYYED MOHSEN, NEMATOLLAHI MOHAMMAD HADI, JAFARI ELHAM, MEHRABANI MITRA, MEHDIPOUR MOHAMMAD, SHEIKHSHOAEE ZAHRA, MANDEGARY ALI. ACCELERATED BURN WOUND CLOSURE IN MICE WITH A NEW FORMULA BASED ON TRADITIONAL MEDICINE. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2016;18(11):0-0. Available from: https://sid.ir/paper/293457/en

IEEE: Copy

MEHRNAZ MEHRABANI, SEYYED MOHSEN SEYYEDKAZEMI, MOHAMMAD HADI NEMATOLLAHI, ELHAM JAFARI, MITRA MEHRABANI, MOHAMMAD MEHDIPOUR, ZAHRA SHEIKHSHOAEE, and ALI MANDEGARY, “ACCELERATED BURN WOUND CLOSURE IN MICE WITH A NEW FORMULA BASED ON TRADITIONAL MEDICINE,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 18, no. 11, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/293457/en

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