مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

49
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

7
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ROLE OF IL28-B POLYMORPHISM (RS12979860) ON SUSTAINED VIROLOGICAL RESPONSE TO PEGYLATED INTERFERON/RIBAVIRIN IN IRANIAN PATIENTS WITH CHRONIC HEPATITIS C

Pages

  0-0

Abstract

 Background: The current medical treatment for HEPATITIS C VIRUS (HCV) infection is pegylated interferon plus ribavirin, but just 50% of genotype 1 HCV patients and about 80% of HCV genotype 3 patients are treated completely. Recently, the RS12979860 C/T polymorphism, which is located 3 kb upstream of the IL28b gene that codes IFN3, shows a powerful association in response to the treatment in HCV patients.Objectives: The aim of this study was to evaluate the relationship between IL28b single nucleotide polymorphism (SNP) and treatment outcomes among chronic HCV patients in IRAN.Patients and Methods: In this cross-sectional study, 108 blood samples were collected from chronic patients in IRAN; 50 unrelated healthy subject samples were also collected. Genomic DNA was extracted, and RS12979860 SNP was done by PCR-RFLP. Finally, products were detected on 12% polyacrylamide gel electrophoresis.Results: The analysis of data for C/T SNP showed that the CC genotype is more common in the control group than in the group of patients. In contrast, the frequency of TT as a mutant genotype is more frequent in patients than in uninfected people. In addition, results showed a statistically significant relationship between CC, CT, and TT genotypes in sensitive and resistant groups (P value:< 0.001, Or: 0.003, CI: 0-0.047). This relationship was also examined in terms of allele frequency, to determine whether the possibility of resistance to treatment in patients with T allele is more than in patients who carry C allele (P value:<0.001).Conclusions: These results showed a significant effect between RS12979860 SNP and sustained virological response (SVR) rate in IRANian patients with chronic HCV. To decrease the cost of long treatments and to prevent severe side effects, determining this polymorphism at the beginning of treatment can be very helpful for patients and physicians.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    DANESHVAR, MAHTAB, NIKBIN, MEHRI, Talebi, Solmaz, JAVADI, FOOZIEH, AGHASADEGHI, MOHAMMAD REZA, MAHMAZI, SANAZ, & SADAT, SEYED MEHDI. (). . , (), -. SID. https://sid.ir/paper/293513/en

    Vancouver: Copy

    DANESHVAR MAHTAB, NIKBIN MEHRI, Talebi Solmaz, JAVADI FOOZIEH, AGHASADEGHI MOHAMMAD REZA, MAHMAZI SANAZ, SADAT SEYED MEHDI. . [Internet]. ;():-. Available from: https://sid.ir/paper/293513/en

    IEEE: Copy

    MAHTAB DANESHVAR, MEHRI NIKBIN, Solmaz Talebi, FOOZIEH JAVADI, MOHAMMAD REZA AGHASADEGHI, SANAZ MAHMAZI, and SEYED MEHDI SADAT, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/293513/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button