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Title

ASSOCIATION OF PERILIPIN AND INSULIN RECEPTOR SUBSTRATE-1 GENES POLYMORPHISM WITH LIPID PROFILES, CENTRAL OBESITY, AND TYPE 2 DIABETES IN A SAMPLE OF AN IRANIAN POPULATION

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Abstract

 Background: Since insulin receptor substrate-1 (IRS-1) is the main substrate of the insulin receptor tyrosine kinase and has been detected to activate phosphatidylinositol (PI) 3-kinase and promote GLUT4 translocation, theIRS-1 gene is a possible candidate for development of type2 diabetes, insulin resistance, and OBESITY. Preilipin (PLIN) coats intracellular lipid droplets and modulates adipocyte lipolysis.Objectives: In this study, we investigated whether insulin receptor substrate-1 (IRS-1) and Perilipin (PLIN) genes polymorphism were associated with TYPE 2 DIABETES (T2D), OBESITY, and LIPID PROFILES in a sample of the Iranian population (Southeast of Iran).Methods: In this randomized case-control study (Feb, 2016 to Sep, 2016), we genotyped 200 patients with T2D and the same number (200) of controls by using the combined nested-polymerase chain reaction (PCR) as well as the amplification refractory mutation system (ARMS) -PCR forIRS-1 variant and Tetra-ARMS-PCR for PLIN variant in southeast Iran (Zahedan).Results: The polymorphism of 4578621 in the PLIN gene was associated with T2D. GG genotype and G allele at rs4578621of PLIN gene were significantly higher in patients than in controls (for the Gallele: OR=2.31, 95%CI=1.55 - 3.46, P<0.0001; for the GG genotype: OR =OR=2.67, 95%CI=1.71-4.19, P<0.0001). Furthermore, women with fast blood glucose (FBG)<110 mg/dL are in protection of diabetes (P<0.001, OR=0.561 (0.430 - 0.733), for women, (P=0.002, OR=0.481 95%CI: 0.305 - 0.756), for FBG, (P=0.002, OR=0.591, 95%CI= 0.422 - 0.829), for triglyceride (TG)<130 mg/dL, and (P=0.001, OR.=0.563, 95%CI=0.407 - 0.780) for TG³ 130. On the other hand, the polymorphism of 2943641 inIRS-1 gene was not associated with T2D (P=0.08). However, the frequencies of the risk A allele at rs29436411ofIRS-1 was significantly higher in patients than in controls (G allele: OR=0.55, 95% CI=0.36 - 0.848, P=0.0086). Also detected, BMI³ 25 is a risk factor for diabetes in rs29436411of IRS-1 gene (P=0.024, OR=1.604 95%CI=1.063 - 2.420).Conclusions: The rs2943641 polymorphism of the IRS-1 gene is a major genetic determinant of OBESITY but not TYPE 2 DIABETES and LIPID PROFILES. The rs4578621 polymorphism of the PLIN gene related with T2D and TG but not OBESITY.

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    APA: Copy

    SARAVANI, RAMIN, NOORZEHI, NAFISEH, Galavi, Hamid Reza, Ranjbar, Nasrin, & LOTFIAN SARGAZI, MARZIEH. (2017). ASSOCIATION OF PERILIPIN AND INSULIN RECEPTOR SUBSTRATE-1 GENES POLYMORPHISM WITH LIPID PROFILES, CENTRAL OBESITY, AND TYPE 2 DIABETES IN A SAMPLE OF AN IRANIAN POPULATION. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(6), 0-0. SID. https://sid.ir/paper/293572/en

    Vancouver: Copy

    SARAVANI RAMIN, NOORZEHI NAFISEH, Galavi Hamid Reza, Ranjbar Nasrin, LOTFIAN SARGAZI MARZIEH. ASSOCIATION OF PERILIPIN AND INSULIN RECEPTOR SUBSTRATE-1 GENES POLYMORPHISM WITH LIPID PROFILES, CENTRAL OBESITY, AND TYPE 2 DIABETES IN A SAMPLE OF AN IRANIAN POPULATION. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(6):0-0. Available from: https://sid.ir/paper/293572/en

    IEEE: Copy

    RAMIN SARAVANI, NAFISEH NOORZEHI, Hamid Reza Galavi, Nasrin Ranjbar, and MARZIEH LOTFIAN SARGAZI, “ASSOCIATION OF PERILIPIN AND INSULIN RECEPTOR SUBSTRATE-1 GENES POLYMORPHISM WITH LIPID PROFILES, CENTRAL OBESITY, AND TYPE 2 DIABETES IN A SAMPLE OF AN IRANIAN POPULATION,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 6, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293572/en

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