EVALUATING THE EFFECT OF THE RS2229238 AND THE RS4845625 INTERLEUKIN 6 RECEPTOR GENE POLYMORPHISMS ON BODY MASS INDEX AND THE RISK OF TYPE 2 DIABETES IN AN IRANIAN STUDY POPULATION

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Galavi Hamid Reza; SARAVANI RAMIN; ALAMDARI ALI REZA; Ranjbar Nasrin; DAMANI ELHAME; NAKHZARI KHODAKHIER TOOBA

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Journal: International Journal of High Risk Behaviors and Addiction Year:2016 | Volume:5 | Issue:4 Page(s): 0-0

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Title

EVALUATING THE EFFECT OF THE RS2229238 AND THE RS4845625 INTERLEUKIN 6 RECEPTOR GENE POLYMORPHISMS ON BODY MASS INDEX AND THE RISK OF TYPE 2 DIABETES IN AN IRANIAN STUDY POPULATION

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HYPERGLYCEMIA

INFLAMMATION

DIABETIC

Abstract

Background: Type 2 diabetes (T2D) is an inflammatory disease that may cause inflammatory responses if it is not controlled; and mayalso lead to clinical manifestations such as retinopathy, nephropathy, and neuropathy. Interleukin 6 (IL6) is an important proinflammatory cytokine that controls the influence of systemic INFLAMMATION on acute phase responses. To work effectively, IL6 must bind with its IL6 receptor (IL6R).Objectives: The current study aimed to investigate the possible associations between two IL6R polymorphisms, namely, rs2229238 and rs4845625, and their susceptibility to T2D.Patients and Methods: This case-control study was done on 250 T2D patients and 250 healthy individuals. The polymorphisms were genotyped using an amplification refractory mutation system-polymerase chain reaction (ARMS-PCR).Results: Our findings showed that either the rs2229238 or the rs4845625 variant was associated with T2D in a sample of the Iranian population. The rs2229238 C/T polymorphism showed a strong significant difference in the CT genotype (OR=0.38, %95 CI=0.23 -0.65, P=0.000), as well as in the TT genotype (OR=0.18, %95 CI=0.05 - 0.63, P=0.007) as a protective factor against T2D in both the patient and the control group. In contrast, the rs4845625 C/T polymorphism showed a significant difference in the CT genotype (OR=1.92, %95 CI=1.15 - 3.23, P=0.031) and in the TT genotype (OR=1.59, %95 CI=1.08 - 2.38, P=0.021) as a risk factor for T2D in both the patient and the control group. An investigation of the alleles relating to these single nucleotide polymorphisms (SNPs) showed that the T allele of rs2229238 (OR=0.34, %95 CI=0.22 - 0.52, P=0.000) and the T allele of rs4845625 (OR=1.43, % 95 CI=1.11 - 1.84, P= 0.006) were significantly different between the subject and control groups, and that these two polymorphisms play a protective and a risk factor role in T2D, respectively. A statistical analysis of the demographic and clinical data showed no significant association between the CC genotype and the CT+TT genotype: in the patient group, with the exception of body mass index (BMI) (P=0.023) in the rs4845625 polymorphism and in the control group, with the exception of HDL (P=0.025) in the rs2229238 SNP.Conclusions: We identified a strong association between the T allele of IL6R gene polymorphisms (rs2229238, rs4845625) and the risk of T2D in a protective role and as a risk factor, respectively. We also found different BMI and HDL values between the patient group and the control group, respectively in compare genotypes (CT+TT vs. CC). Further studies on various ethnicities are necessary to verify our findings.

Cites

ASSOCIATION OF PERILIPIN AND INSULIN RECEPTOR SUBSTRATE-1 GENES POLYMORPHISM WITH LIPID PROFILES, CENTRAL OBESITY, AND TYPE 2 DIABETES IN A SAMPLE OF AN IRANIAN POPULATION

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APA: Copy

Galavi, Hamid Reza, SARAVANI, RAMIN, ALAMDARI, ALI REZA, Ranjbar, Nasrin, DAMANI, ELHAME, & NAKHZARI KHODAKHIER, TOOBA. (2016). EVALUATING THE EFFECT OF THE RS2229238 AND THE RS4845625 INTERLEUKIN 6 RECEPTOR GENE POLYMORPHISMS ON BODY MASS INDEX AND THE RISK OF TYPE 2 DIABETES IN AN IRANIAN STUDY POPULATION. INTERNATIONAL JOURNAL OF HIGH RISK BEHAVIORS AND ADDICTION, 5(4), 0-0. SID. https://sid.ir/paper/330830/en

Vancouver: Copy

Galavi Hamid Reza, SARAVANI RAMIN, ALAMDARI ALI REZA, Ranjbar Nasrin, DAMANI ELHAME, NAKHZARI KHODAKHIER TOOBA. EVALUATING THE EFFECT OF THE RS2229238 AND THE RS4845625 INTERLEUKIN 6 RECEPTOR GENE POLYMORPHISMS ON BODY MASS INDEX AND THE RISK OF TYPE 2 DIABETES IN AN IRANIAN STUDY POPULATION. INTERNATIONAL JOURNAL OF HIGH RISK BEHAVIORS AND ADDICTION[Internet]. 2016;5(4):0-0. Available from: https://sid.ir/paper/330830/en

IEEE: Copy

Hamid Reza Galavi, RAMIN SARAVANI, ALI REZA ALAMDARI, Nasrin Ranjbar, ELHAME DAMANI, and TOOBA NAKHZARI KHODAKHIER, “EVALUATING THE EFFECT OF THE RS2229238 AND THE RS4845625 INTERLEUKIN 6 RECEPTOR GENE POLYMORPHISMS ON BODY MASS INDEX AND THE RISK OF TYPE 2 DIABETES IN AN IRANIAN STUDY POPULATION,” INTERNATIONAL JOURNAL OF HIGH RISK BEHAVIORS AND ADDICTION, vol. 5, no. 4, pp. 0–0, 2016, [Online]. Available: https://sid.ir/paper/330830/en

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