EMERGENCE OF BLAOXA-CARRYING CARBAPENEM RESISTANCE IN MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII IN THE INTENSIVE CARE UNIT

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BAGHERI JOSHEGHANI SAREH; MONIRI REZVAN; FIROOZEH FARZANEH; SEHAT MOJTABA; DASTEHGOLI KAMRAN; Koosha Hasan; KHALTABADI FARAHANI REZA

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Journal: Iranian Red Crescent Medical Journal Year:2017 | Volume:19 | Issue:5 Page(s): 0-0

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Title

EMERGENCE OF BLAOXA-CARRYING CARBAPENEM RESISTANCE IN MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII IN THE INTENSIVE CARE UNIT

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Keywords

CARBAPENEM

ANTIBIOTIC RESISTANCE

INTENSIVE CARE UNIT

ACINETOBACTER BAUMANNII

Abstract

Background: Emergence of multidrug-resistant (MDR) ACINETOBACTER BAUMANNII infections is becoming a worldwide threat to hospitalized patients, particularly in INTENSIVE CARE UNITs.Objectives: The aim of this study was to investigate the antimicrobial susceptibility patterns and prevalence of blaOXA-type CARBAPENEMases of A. baumannii isolates in a teaching hospital in Iran.Patients and Methods: The study included a total of 40 isolates of CARBAPENEM-resistant A. baumannii, obtained from 103 tracheal tubes in hospitalized ICU patients.Antimicrobial susceptibility testing was performed according to CLSI guidelines. Thebla OXA-51, bla OXA-23, bla OXA-24, bla OXA-58, and IS Aba1 genes were detected by PCR.Results: All of the A. baumannii isolates were resistant to imipenem and meropenem, and 100% of the isolates were MDR. The bla OXA-51 and IS Aba1 genes were detected in 100% of the isolates.bla OXA-23 and bla OXA-24 were detected in 90% and 40% of the isolates, respectively, but bla OXA-58 was absent in the A. baumannii isolates. In addition, 32.5% of CARBAPENEM-resistant strains contained at least three genes encodingbla OXA-type CARBAPENEMase. Colistin and polymyxin B were the most effective antibiotics.The sole risk factor for infection of hospitalized patients with CARBAPENEM-resistant Acinetobacter strains was age over 40 years (P=0.042). The mortality rate was 27.5%.Conclusions: These findings signify the alarming spread of OXAgenes in A. baumannii strains in our INTENSIVE CARE UNIT. The spread of CARBAPENEM-resistant Acinetobacter strains has serious health implications and requires the application of strict infection-control measures.

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APA: Copy

BAGHERI JOSHEGHANI, SAREH, MONIRI, REZVAN, FIROOZEH, FARZANEH, SEHAT, MOJTABA, DASTEHGOLI, KAMRAN, Koosha, Hasan, & KHALTABADI FARAHANI, REZA. (2017). EMERGENCE OF BLAOXA-CARRYING CARBAPENEM RESISTANCE IN MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII IN THE INTENSIVE CARE UNIT. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(5), 0-0. SID. https://sid.ir/paper/293595/en

Vancouver: Copy

BAGHERI JOSHEGHANI SAREH, MONIRI REZVAN, FIROOZEH FARZANEH, SEHAT MOJTABA, DASTEHGOLI KAMRAN, Koosha Hasan, KHALTABADI FARAHANI REZA. EMERGENCE OF BLAOXA-CARRYING CARBAPENEM RESISTANCE IN MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII IN THE INTENSIVE CARE UNIT. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(5):0-0. Available from: https://sid.ir/paper/293595/en

IEEE: Copy

SAREH BAGHERI JOSHEGHANI, REZVAN MONIRI, FARZANEH FIROOZEH, MOJTABA SEHAT, KAMRAN DASTEHGOLI, Hasan Koosha, and REZA KHALTABADI FARAHANI, “EMERGENCE OF BLAOXA-CARRYING CARBAPENEM RESISTANCE IN MULTIDRUG-RESISTANT ACINETOBACTER BAUMANNII IN THE INTENSIVE CARE UNIT,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 5, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293595/en

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