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Title

EFFECT OF INTENSIVE EXERCISE TRAINING AND VITAMIN E SUPPLEMENTATION ON THE CONTENT OF RAT BRAIN-DRIVED NEUROTROPHIC FACTORS

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Abstract

 Background: HYDROGEN PEROXIDE (H2O2) and TUMOR NECROSIS FACTOR ALPHA (TNF-a) increase BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) and GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR (GDNF) expression. Athletics use anti-oxidant and anti-inflammatory supplementations to reduce H2O2 and TNF-a level. There is insufficient information about VITAMIN E supplementation on neurotrophic adaptations induced by intensive EXERCISE training.Objectives: The aim of the present study was to investigate the effects of intensive EXERCISE training in combination with VITAMIN E supplementation on BDNF and GDNF content of rat brain.Methods: In an experimental study in Iran, 40 male Wistar rats were randomly assigned to Control (C), Sham (S), VITAMIN E (V.TE), EXERCISE training (ET), EXERCISE training+Vitamin E (ET+V.TE) groups, with 8 rats in each group. EXERCISE training on treadmill (27 m/minute) was carried out in combination with VITAMIN E supplementation (60 mg/kg/day) for six weeks. Statistical significance was determined at P<0.05 using one-way analysis of variance (SPSS software, version 16.0).Results: VITAMIN E supplementation increased brain VITAMIN E levels in V.TE and ET+V.TE groups (P=0.001). Significant increments in the levels of H2O2 (P=0.007), TNF-a, (P=0.001), BDNF (P=0.001), and GDNF (P=0.001) in the ET group were shown; however, VITAMIN E supplementation could not change EXERCISE-induced increases on the above-mentioned factors in the ET+V.TE group (the p-values were equal to 0.024, 0.001, 0.001, and 0.001 respectively).Conclusion: Intensive EXERCISE training increases BDNF and GDNF contents in the whole brain of rats, yet VITAMIN E does not influence neurotrophic adaptations induced by intensive EXERCISE training.

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APA: Copy

FOADODDINI, MOHSEN, AFZALPOUR, MOHAMMAD ESMAEIL, TAHERI CHADORNESHIN, HOSSEIN, & ABTAHI EIVARY, SEYED HOSEIN. (2018). EFFECT OF INTENSIVE EXERCISE TRAINING AND VITAMIN E SUPPLEMENTATION ON THE CONTENT OF RAT BRAIN-DRIVED NEUROTROPHIC FACTORS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(2), 0-0. SID. https://sid.ir/paper/293671/en

Vancouver: Copy

FOADODDINI MOHSEN, AFZALPOUR MOHAMMAD ESMAEIL, TAHERI CHADORNESHIN HOSSEIN, ABTAHI EIVARY SEYED HOSEIN. EFFECT OF INTENSIVE EXERCISE TRAINING AND VITAMIN E SUPPLEMENTATION ON THE CONTENT OF RAT BRAIN-DRIVED NEUROTROPHIC FACTORS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(2):0-0. Available from: https://sid.ir/paper/293671/en

IEEE: Copy

MOHSEN FOADODDINI, MOHAMMAD ESMAEIL AFZALPOUR, HOSSEIN TAHERI CHADORNESHIN, and SEYED HOSEIN ABTAHI EIVARY, “EFFECT OF INTENSIVE EXERCISE TRAINING AND VITAMIN E SUPPLEMENTATION ON THE CONTENT OF RAT BRAIN-DRIVED NEUROTROPHIC FACTORS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 2, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293671/en

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