STUDY OF IN VITRO AND IN VIVO EFFECTS OF DESCURAINIA SOPHIA EXTRACT ON HYMENOLEPIS
NANA IN COMPARISON WITH NICLOSAMIDE.

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MARAGHI S.; TORFI JABRPOOR N.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Hakim Journal Year:2002 | Volume:5 | Issue:1 Page(s): 57-62

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Title

STUDY OF IN VITRO AND IN VIVO EFFECTS OF DESCURAINIA SOPHIA EXTRACT ON HYMENOLEPIS NANA IN COMPARISON WITH NICLOSAMIDE.

Author(s)

MARAGHI S. | TORFI JABRPOOR N. | Issue Writer Certificate

Keywords

HYMERWLEPIS NANAQ4

EXTRACTQ4

DESCURAINIA SOPHIA; NICLOSAMIDE.Q4

Abstract

In vitro effect of different concentrations(6.35, 12.07, 25.4, 31.76, 38.11, 44.46, 50.81, 57.16 and 63,51 mg/ml distilled water) of hydroalcoholic EXTRACT of Descurainia sophia and Niclosamide (10, 20, 30, 40, and 50 mg/ml distilled water) effected mature Hymenolepis nana prepared from mice intestine and mean sacrificing time of Hymenolepis nana in each concentration was measured.In conirol mice nonnal saline was used. Time to kill parasites in the concentration of 50.81 mg/ml of EXTRACT was 3.55 minutes, close to the mean time of using 40 mg/ml.Niclosamide (3.61 minutes). The worms used as control remained alive after 24 hours. For in vivo the concentrations of EXTRACT (50.8 mg/ml) and niclosamide (40 mg/ml) were given oridly as a single dose (0.3 ml) daily for seven days to white mice infected with Hymenolepis nana (30 micefor treatment with EXTRACT, 30 mice for niclosamide). The control mice were given nonnal saline. At the end of treatment, the mice were sacrified and assessed for any infection. The EXTRACT and Niclosamide were 63.7% and 90% effective in treating parasitized mice respectively. In the case of repeating the course of treatment with EXTRACT and Niclosamide(totally 14 days) the effectiveness raised to 76.6% and 96.6%, respectively, indicated that the EXTRACT was less effective in treatment trial. By increasing the concentration of the EXTRACT to 63.51 mg/ml, the tHerapeutic effects affter 7 and 14 days was increased to 86.6% and 90% respectively. We conclude that administration of hydroalcoholicextract of Descurainid sophia with the concentration of 63.51 mg/ml daily as a single dose for 7 days can cure infected mice with Hymenolepis nana.

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APA: Copy

MARAGHI, S., & TORFI JABRPOOR, N.. (2002). STUDY OF IN VITRO AND IN VIVO EFFECTS OF DESCURAINIA SOPHIA EXTRACT ON HYMENOLEPIS NANA IN COMPARISON WITH NICLOSAMIDE.. HAKIM RESEARCH JOURNAL, 5(1), 57-62. SID. https://sid.ir/paper/29370/en

Vancouver: Copy

MARAGHI S., TORFI JABRPOOR N.. STUDY OF IN VITRO AND IN VIVO EFFECTS OF DESCURAINIA SOPHIA EXTRACT ON HYMENOLEPIS NANA IN COMPARISON WITH NICLOSAMIDE.. HAKIM RESEARCH JOURNAL[Internet]. 2002;5(1):57-62. Available from: https://sid.ir/paper/29370/en

IEEE: Copy

S. MARAGHI, and N. TORFI JABRPOOR, “STUDY OF IN VITRO AND IN VIVO EFFECTS OF DESCURAINIA SOPHIA EXTRACT ON HYMENOLEPIS NANA IN COMPARISON WITH NICLOSAMIDE.,” HAKIM RESEARCH JOURNAL, vol. 5, no. 1, pp. 57–62, 2002, [Online]. Available: https://sid.ir/paper/29370/en

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