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Information Journal Paper

Title

COMPARING THE EFFECTIVENESS OF INTRA-ARTICULAR PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION UNDER ULTRASOUND GUIDANCE ON PAIN CONTROL OF KNEE OSTEOARTHRITIS

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Abstract

 Background: KNEE OSTEOARTHRITIS is one of the most prevalent and disabling diseases worldwide, which decreases patients’ qualityof life (QoL). However, pharmacological and non-pharmacological treatments, apart from complications, could not desirablycontrol the disease. Objectives: The current study aimed at evaluating the effect of two methods of INTRA-ARTICULAR INJECTION of PLATELET-RICH PLASMA (PRP)and CORTICOSTEROID on PAIN control of KNEE OSTEOARTHRITIS. Methods: A randomized clinical trial was performed on 67-patients with grades II-III of KNEE OSTEOARTHRITIS (OA) referring to PAINclinic of a referral, university-affiliated hospital, Rasht, Iran, from April 2016 to June 2017. Patients were randomly divided into twogroups: TRIAMCINOLONE (T) (n=34) and PRP (P) (n=33) by quadruple block. In the group T, 40mgTriamcinolone and in the group P, PRPwas injected INTRA-ARTICULARly, under ultrasound-guidance, once a month, for three consecutive months. Patients’ PAIN intensity wasevaluated based on the Visual Analog Scale (VAS), and their outcome was determined based on the KNEE injury and OSTEOARTHRITISOutcome Score (KOOS) monthly for three consecutive months, as well as six months after the treatment. Results: There were no significant differences between the groups regarding demographic characteristics. VAS assessments indicatedlower PAIN scores in the group P than group T; the difference between the groups was statistically significant two, three, andsix months after the INJECTIONs. In the group P, the mean initial VAS was 7. 36  0. 92 compared with 7. 12  1. 29 in the group T (P =0. 385). After six months, the scores dropped to 3. 45 0. 86 and 4. 81 1. 4, respectively (P = 0. 0001). Examination of the KOOS parametersshowed a significant association between treatment outcomes in the group P than the group T. Therefore, the test showed asignificant difference between the groups regarding relief of PAIN, improvement of symptoms and activities of daily living (ADL)two, three, and six months after treatment. There was also a significant difference between the groups in terms of the quality oflife (QoL) and doing sport activities three and six months after the treatment (P < 0. 05). Based on the repeated measures analysis, asignificant inter-and INTRA-group differences in themeanscore of KOOSparameters was observed between the intervals (P = 0. 0001). Conclusions: The current study resultsshowedthat three INTRA-ARTICULAR INJECTIONs of TRIAMCINOLONEandPRP could reduce PAINandimprove ARTICULAR function in patients with grades II-III KNEE OSTEOARTHRITIS. However, PAIN relief and improvement in the outcomeswere more effective and more prolonged secondary to PRP INJECTIONs than CORTICOSTEROIDs.

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    APA: Copy

    NADERI NABI, BAHRAM, SEDIGHINEJAD, ABBAS, MARDANI KIVI, MOHSEN, HAGHIGHI, MOHAMMAD, ATRKAR ROUSHAN, ZAHRA, GHAZANFAR TEHRAN, SAMANEH, & BIAZAR, GELAREH. (2018). COMPARING THE EFFECTIVENESS OF INTRA-ARTICULAR PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION UNDER ULTRASOUND GUIDANCE ON PAIN CONTROL OF KNEE OSTEOARTHRITIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(3), 0-0. SID. https://sid.ir/paper/293700/en

    Vancouver: Copy

    NADERI NABI BAHRAM, SEDIGHINEJAD ABBAS, MARDANI KIVI MOHSEN, HAGHIGHI MOHAMMAD, ATRKAR ROUSHAN ZAHRA, GHAZANFAR TEHRAN SAMANEH, BIAZAR GELAREH. COMPARING THE EFFECTIVENESS OF INTRA-ARTICULAR PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION UNDER ULTRASOUND GUIDANCE ON PAIN CONTROL OF KNEE OSTEOARTHRITIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(3):0-0. Available from: https://sid.ir/paper/293700/en

    IEEE: Copy

    BAHRAM NADERI NABI, ABBAS SEDIGHINEJAD, MOHSEN MARDANI KIVI, MOHAMMAD HAGHIGHI, ZAHRA ATRKAR ROUSHAN, SAMANEH GHAZANFAR TEHRAN, and GELAREH BIAZAR, “COMPARING THE EFFECTIVENESS OF INTRA-ARTICULAR PLATELET-RICH PLASMA AND CORTICOSTEROID INJECTION UNDER ULTRASOUND GUIDANCE ON PAIN CONTROL OF KNEE OSTEOARTHRITIS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293700/en

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