ANTIOXIDANT STATUS, LIPID PEROXIDATION AND PROTEIN OXIDATION IN TYPE 2DIABETIC PATIENTS; BENEFICIAL EFFECTS OF SUPPLEMENTATION WITHCARNOSINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

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HOUJEGHANI SHIVA; KHEIROURI SORAYA; FARAJI ESMAEIL; ASGHARI JAFARABADI MOHAMMAD; JABBARI MASOUMEH

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Journal: Iranian Red Crescent Medical Journal Year:2018 | Volume:20 | Issue:3 Page(s): 0-0

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Title

ANTIOXIDANT STATUS, LIPID PEROXIDATION AND PROTEIN OXIDATION IN TYPE 2DIABETIC PATIENTS; BENEFICIAL EFFECTS OF SUPPLEMENTATION WITHCARNOSINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

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Keywords

ANTIOXIDANT

CARNOSINE

DIABETES MELLITUS

TYPE 2

LIPID PEROXIDATION

PROTEIN OXIDATION

TYPE 2

Abstract

Background: Oxidative stress in the pathogenesis of diabetes is of great prominence and that CARNOSINE is a natural ANTIOXIDANT. Objectives: This study was aimed to investigate the effect of CARNOSINE supplementation on different oxidative stress biomarkersin patients with TYPE 2 DIABETES MELLITUS (T2DM). Methods: In this randomized, double-blind placebo-controlled trial, 54 patients with T2DM were employed from Tabriz Sheikhorraeespolyclinic and Imam-Reza Hospital endocrine center, and assigned to either the intervention group (n = 27) to receive two capsulesof CARNOSINE 500 mg each or the control group (n = 27) to take two capsules of crystalline microcellulose for 12 weeks. Serumlevels of fasting blood sugar (FBS), malondialdehyde (MDA), protein carbonyl (PC) and erythrocytes content of catalase (CAT), andsuperoxide dismutase (SOD) were assessed before and after the supplementation. Results: A total of 44 patients completed the study. Anthropometric indices and energy intake did not show a significant changein both studied groups. Improved catalase level and decreased serum levels of fasting blood sugar, malondialdehyde and proteincarbonyl occurred in the CARNOSINE group compared to the placebo group after adjusting for baseline values and confounders (P <0. 05). Between-group differences were not significant for other variables at the end of the research. In the placebo group, none ofthe studied biomarkers were altered significantly. Conclusions: Our findings divulge the beneficial effects of CARNOSINE supplementation in improving the ANTIOXIDANT status andattenuating some of the oxidative stress biomarkers in patients with T2DM making it a useful adjunct therapy.

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APA: Copy

HOUJEGHANI, SHIVA, KHEIROURI, SORAYA, FARAJI, ESMAEIL, ASGHARI JAFARABADI, MOHAMMAD, & JABBARI, MASOUMEH. (2018). ANTIOXIDANT STATUS, LIPID PEROXIDATION AND PROTEIN OXIDATION IN TYPE 2DIABETIC PATIENTS; BENEFICIAL EFFECTS OF SUPPLEMENTATION WITHCARNOSINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 20(3), 0-0. SID. https://sid.ir/paper/293702/en

Vancouver: Copy

HOUJEGHANI SHIVA, KHEIROURI SORAYA, FARAJI ESMAEIL, ASGHARI JAFARABADI MOHAMMAD, JABBARI MASOUMEH. ANTIOXIDANT STATUS, LIPID PEROXIDATION AND PROTEIN OXIDATION IN TYPE 2DIABETIC PATIENTS; BENEFICIAL EFFECTS OF SUPPLEMENTATION WITHCARNOSINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2018;20(3):0-0. Available from: https://sid.ir/paper/293702/en

IEEE: Copy

SHIVA HOUJEGHANI, SORAYA KHEIROURI, ESMAEIL FARAJI, MOHAMMAD ASGHARI JAFARABADI, and MASOUMEH JABBARI, “ANTIOXIDANT STATUS, LIPID PEROXIDATION AND PROTEIN OXIDATION IN TYPE 2DIABETIC PATIENTS; BENEFICIAL EFFECTS OF SUPPLEMENTATION WITHCARNOSINE: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 20, no. 3, pp. 0–0, 2018, [Online]. Available: https://sid.ir/paper/293702/en

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