مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

THE EFFECT OF NALTREXONE ON MEMORY DEFICIT FOLLOWED BYELECTROCONVULSIVE THERAPY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL

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Abstract

 Background: ELECTROCONVULSIVE THERAPY (ECT) is famously known as a treatment for depression; however, memory impairmentshave always been a point of concern. The use of opioid antagonists may protect against the development of MEMORY DEFICITs afterECT. The current study aimed at assessing the effect of NALTREXONE in diminishing memory impairments. Methods: This randomized, double-blinded, placebo-controlled clinical trial took place at Imam Hossein hospital of Tehran/Iran. Patients diagnosed withMDD, were assigned to either NALTREXONE or placebo and received 6 sessions of ECT within 2 weeks. WechslerMemory Scale was performed the day before the first session of ECT, as well as 2 weeks, 1 and 3 months after finishing the 6th session. The Hamilton depression rating scale was performed 2 times to examine the possible interference caused by depression or to relapseas a confounding variable. Results: Patients receiving NALTREXONE and placebo showed no significant difference in WMS scores. However, after further assessment, changes of WMS scores in every round were compared; the results showed that after 2 weeks from baseline, the amount ofthe reduction of total WMS scores from baseline was significantly lower in the NALTREXONE group (P = 0. 04). Conclusions: This study suggests that NALTREXONE as compared to placebo has no advantageous effect on attenuating memorydeficits in the long term. It is a smaller degree of memory decline that makes NALTREXONE superior to placebo.

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    APA: Copy

    MOTAZEDIAN, SOMAYEH, NOORBAKHSH, SIMASADAT, SHAMS, JAMAL, JAFARI, REYHANEH, FAGHIHI MOHAMADI, MOHAMAD MAHDI, & ZAHIRODDIN, ALIREZA. (2017). THE EFFECT OF NALTREXONE ON MEMORY DEFICIT FOLLOWED BYELECTROCONVULSIVE THERAPY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(9), 0-0. SID. https://sid.ir/paper/293740/en

    Vancouver: Copy

    MOTAZEDIAN SOMAYEH, NOORBAKHSH SIMASADAT, SHAMS JAMAL, JAFARI REYHANEH, FAGHIHI MOHAMADI MOHAMAD MAHDI, ZAHIRODDIN ALIREZA. THE EFFECT OF NALTREXONE ON MEMORY DEFICIT FOLLOWED BYELECTROCONVULSIVE THERAPY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(9):0-0. Available from: https://sid.ir/paper/293740/en

    IEEE: Copy

    SOMAYEH MOTAZEDIAN, SIMASADAT NOORBAKHSH, JAMAL SHAMS, REYHANEH JAFARI, MOHAMAD MAHDI FAGHIHI MOHAMADI, and ALIREZA ZAHIRODDIN, “THE EFFECT OF NALTREXONE ON MEMORY DEFICIT FOLLOWED BYELECTROCONVULSIVE THERAPY: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 9, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293740/en

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