مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Title

EFFECT OF EXTRACELLULAR VESICLES DERIVED FROM MESENCHYMAL STEM CELLSON K-562 LEUKEMIA CELL LINE

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Abstract

 Background: Several studies show that MESENCHYMAL STEM CELLs (MSCs) possess anti-tumor properties, while other studies showthat MSCs may promote cancer. EXTRACELLULAR VESICLES (EVs) are identified as novel mediators to communicate among cells, whichmay be used as vehicles to transfer the MSC information to the target cells. Objectives: The current study aimed at investigating whether the human umbilical cord MESENCHYMAL STEM CELL (HUSCMSC) derivedextracellular vesicles (EVs) inhibits or promotes TUMOR cell GROWTH in K562 chronic myelogenous LEUKEMIA CELL LINE. Methods: In the current experimental study, trypan blue exclusion and 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide(MTT) assay were performed to investigate the cell viability and metabolic activity. Additionally, flow cytometry was employedto assess cell cycle and apoptosis of K562 CELLs after 72 hours exposure to EVs. Results: The obtained results showed that no doses of EVs inhibited the TUMOR GROWTH (mean  standard deviation (SD) of cellviability at the day 10 was 94. 4 2. 60, P > 0. 05) and metabolic activity in three days (mean SD at the day 3 was 97. 27 2. 46, P >0. 05). Furthermore, EVs also did not change the apoptosis rate (mean SD at the day 3 was 3. 17 2. 34 for annexin positive cells, and3. 36 1. 91 for annexin/propidium iodide (PI)-positive cells, P > 0. 05). Conclusions: In conclusion, no significant changes in TUMOR cell GROWTH were observed after treating K562 CELLs with MSCs-derivedEVs.

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    APA: Copy

    Mardani Valandani, Hajar, AMIRIZADEH, NASER, NIKOUGOFTAR, MAHIN, SAFA, MAJID, MIRZAEE KHALILABADI, ROOHOLLAH, & KAZEMI, AHMAD. (). . , (), -. SID. https://sid.ir/paper/293746/en

    Vancouver: Copy

    Mardani Valandani Hajar, AMIRIZADEH NASER, NIKOUGOFTAR MAHIN, SAFA MAJID, MIRZAEE KHALILABADI ROOHOLLAH, KAZEMI AHMAD. . [Internet]. ;():-. Available from: https://sid.ir/paper/293746/en

    IEEE: Copy

    Hajar Mardani Valandani, NASER AMIRIZADEH, MAHIN NIKOUGOFTAR, MAJID SAFA, ROOHOLLAH MIRZAEE KHALILABADI, and AHMAD KAZEMI, “,” , vol. , no. , pp. –, , [Online]. Available: https://sid.ir/paper/293746/en

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