مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

COMPARING INTRAVENOUS PHENYLEPHRINE AND EPHEDRINE FORHYPOTENSION DURING SPINAL ANESTHESIA FOR ELECTIVE CESAREAN SECTION: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL

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Abstract

 Background: Neuraxial anesthesia is an acceptable technique in pregnant females for CESAREAN SECTION and up to 71% of pregnantpatients have hemodynamic complications, especially HYPOTENSION. Objectives: This study aimed at comparing the effectiveness of PHENYLEPHRINE versus EPHEDRINE in treatment of maternal HYPOTENSIONdue to SPINAL ANESTHESIA for elective CESAREAN SECTION to determine drug efficacy and fewer side effects. Methods: In this randomized double blind clinical study, 124 pregnant females, who were admitted to Ali ibn Abi Talib hospital inZahedan, Iran, between 2015and2016, for elective CESAREAN SECTION, were selected by the Block randomization sampling method. Thesamples were divided to 4 groups: Group I received 5mgephedrine bolus, Group II was administered 10mgbolus EPHEDRINE, GroupIII were delivered PHENYLEPHRINE bolus of 50 mcg, and Group IV 100 mcg PHENYLEPHRINE bolus in case of HYPOTENSION. Neonataloutcome and maternal side effects, hemodynamics changes, and Apgar score were controlled and recorded. Results: In terms of hemodynamic parameters (systolic blood pressure, diastolic blood pressure, and pulse rate), there was a significantdifference between the groups (P < 0. 0001). The umbilical arterial pH value and base excess between EPHEDRINE and PHENYLEPHRINEgroups were significantly different (P < 0. 0001), and fetal acidosis in the EPHEDRINE group was found. Nausea and vomitingwas significant between the 2 groups (P = 0. 03), while the incidence of nausea and vomiting in the EPHEDRINE group was higher thanthe other groups. There was no difference between the 2 groups in the first-and fifth-minute Apgar (P = 1). Conclusions: Control of blood pressure during spinal 50-mcg PHENYLEPHRINE is recommended.

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    APA: Copy

    VAKILI, HEDAYATOLLAH, ENAYATI, HASAN, & DASHIPOUR, ALIREZA. (2017). COMPARING INTRAVENOUS PHENYLEPHRINE AND EPHEDRINE FORHYPOTENSION DURING SPINAL ANESTHESIA FOR ELECTIVE CESAREAN SECTION: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(10), 0-0. SID. https://sid.ir/paper/293764/en

    Vancouver: Copy

    VAKILI HEDAYATOLLAH, ENAYATI HASAN, DASHIPOUR ALIREZA. COMPARING INTRAVENOUS PHENYLEPHRINE AND EPHEDRINE FORHYPOTENSION DURING SPINAL ANESTHESIA FOR ELECTIVE CESAREAN SECTION: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(10):0-0. Available from: https://sid.ir/paper/293764/en

    IEEE: Copy

    HEDAYATOLLAH VAKILI, HASAN ENAYATI, and ALIREZA DASHIPOUR, “COMPARING INTRAVENOUS PHENYLEPHRINE AND EPHEDRINE FORHYPOTENSION DURING SPINAL ANESTHESIA FOR ELECTIVE CESAREAN SECTION: A RANDOMIZED DOUBLE-BLIND CLINICAL TRIAL,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 10, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293764/en

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