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Title

TP53 CODON 72 GENETIC POLYMORPHISM, RS1042522, MODIFIES THEASSOCIATION BETWEEN TOBACCO SMOKING AND BREAST CANCER RISK

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Abstract

 Background: TP53 tumor suppressor gene participates in several pathways involving in carcinogenesis such as cell cycle control, DNA repair, and apoptosis. A common TP53 SNP (guanine/cytosine nucleotide substitution at codon 72), rs1042522, affects the functionof P53 protein and may influence tumor behavior in response to environmental carcinogens. Objectives: This study investigates the association between TP53 codon 72 POLYMORPHISMs, tobacco SMOKING, and breast cancer riskin southern Iranian women from Bushehr. Methods: A case-control study was conducted on 144 cases with histologically confirmed invasive breast carcinoma and 162 randomlyselected healthy controls with no previous cancer history in their family. TP53 codon 72 genotype was determined by usingrestriction fragment length POLYMORPHISM-polymerase chain reaction (RFLP-PCR) technique. Results: Analysis revealed that SMOKING frequency was significantly higher in cases compared to controls (OR = 2. 31, 95%CI = 1. 33-3. 99, P = 0. 003) and the association between SMOKING and breast cancer was only significant for individuals with Arg/Pro genotype (OR =3. 23, 95% CI = 1. 47-7. 06, P = 0. 003). On the other hand, there was no statistically considerable difference in the allele and genotypedistribution between cases and controls. Conclusions: These results should be confirmed in larger studies, but suggest that TP53 Arg/Pro genotype modifies the risk of breastcancer in tobacco smokers and causes significantly more susceptibility to breast cancer due to SMOKING.

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APA: Copy

MORADINASAB, MARYAM, OSTOVAR, AFSHIN, NABIPOUR, IRAJ, EGHBALI, SEYED SAJJAD, VAHDAT, KATAYOUN, GHADERI, ABBAS, FARZANEH, MOHAMAD REZA, & RAVANBOD, MOHAMMAD REZA. (2017). TP53 CODON 72 GENETIC POLYMORPHISM, RS1042522, MODIFIES THEASSOCIATION BETWEEN TOBACCO SMOKING AND BREAST CANCER RISK. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(10), 0-0. SID. https://sid.ir/paper/293769/en

Vancouver: Copy

MORADINASAB MARYAM, OSTOVAR AFSHIN, NABIPOUR IRAJ, EGHBALI SEYED SAJJAD, VAHDAT KATAYOUN, GHADERI ABBAS, FARZANEH MOHAMAD REZA, RAVANBOD MOHAMMAD REZA. TP53 CODON 72 GENETIC POLYMORPHISM, RS1042522, MODIFIES THEASSOCIATION BETWEEN TOBACCO SMOKING AND BREAST CANCER RISK. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(10):0-0. Available from: https://sid.ir/paper/293769/en

IEEE: Copy

MARYAM MORADINASAB, AFSHIN OSTOVAR, IRAJ NABIPOUR, SEYED SAJJAD EGHBALI, KATAYOUN VAHDAT, ABBAS GHADERI, MOHAMAD REZA FARZANEH, and MOHAMMAD REZA RAVANBOD, “TP53 CODON 72 GENETIC POLYMORPHISM, RS1042522, MODIFIES THEASSOCIATION BETWEEN TOBACCO SMOKING AND BREAST CANCER RISK,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 10, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293769/en

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