COMPARISON BETWEEN THE EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN THE TREATMENT OF
OBSESSIVE-COMPULSIVE DISORDER (OCD) AMONG CHILDREN AND ADOLESCENTS

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TORKZABAN R.; MOUMENI F.; MOHAMMADI M.R.; GHELI P.

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Journal: Hakim Journal Year:2002 | Volume:5 | Issue:1 Page(s): 37-42

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Information Journal Paper

Title

COMPARISON BETWEEN THE EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (OCD) AMONG CHILDREN AND ADOLESCENTS

Author(s)

TORKZABAN R. | MOUMENI F. | MOHAMMADI M.R. | GHELI P. | Issue Writer Certificate

Keywords

OBSESSIVE-COMPULSIVE DISORDERQ4

FLUOXETINEQ4

CLOMIPRAMINEQ4

MAUDSELEYQ4

YALE-BROWN.Q4

Abstract

This study was conducted to compare the efficacy of FLUOXETINE and CLOMIPRAMINE in the treatment of OCD in children and adolescents. Twenty one boys and 9 girls ranging in age 7-17 years (mean 12.19 years) included in this study from psychiatric clinic of Roozbeh Hospital. The subjects were diagnosed by the psychiatrist in accordance to DSM-W diagnostic criteria. The clients were randomly assigned into two groups. The first group (10 boys and 5girls) received FLUOXETINE and the second group (11 boys and 4 girls) received CLOMIPRAMINE for 8 weeks. Patients received non-fixed dose of FLUOXETINE (20-60 mg/day) and CLOMIPRAMINE (25-100 mg/day) in a double-blind trial. The severity of OCD was measured at weeks 0, 2, 4 and 8 by using YALE-BROWN.obsessive-compulsive scale (YBOCS) and MAUDSELEY obsessive-compulsive inventory (MOCI)Paired t-test, and Wilcoxn test utilized for " statistical analysis. Results showed that in the FLUOXETINE group total score of YBOCS and MOCI significantly decreased after 8 weeks by 8.3 (p=0.000l) and 4.8 (p=0.0001) respectively compared with baseline score. In the CLOMIPRAMINE group at this interval total score of YBOCS and MOCI decreased by 9.6 (p=0.0001) and 6.3 (p=0.0001) respectively This study noted similar efficacy between FLUOXETINE and CLOMIPRAMINE in the treatment of children, and adolescents with OCD, but FLUOXETINE had the significant effects on boys.

Cites

A META-ANALYSIS ON THE EFFECTIVENESS OF DRUG THERAPY IN IMPROVING OBSESSIVE-COMPULSIVE DISORDER SYMPTOMS

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APA: Copy

TORKZABAN, R., MOUMENI, F., MOHAMMADI, M.R., & GHELI, P.. (2002). COMPARISON BETWEEN THE EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (OCD) AMONG CHILDREN AND ADOLESCENTS . HAKIM RESEARCH JOURNAL, 5(1), 37-42. SID. https://sid.ir/paper/29377/en

Vancouver: Copy

TORKZABAN R., MOUMENI F., MOHAMMADI M.R., GHELI P.. COMPARISON BETWEEN THE EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (OCD) AMONG CHILDREN AND ADOLESCENTS . HAKIM RESEARCH JOURNAL[Internet]. 2002;5(1):37-42. Available from: https://sid.ir/paper/29377/en

IEEE: Copy

R. TORKZABAN, F. MOUMENI, M.R. MOHAMMADI, and P. GHELI, “COMPARISON BETWEEN THE EFFICACY OF FLUOXETINE AND CLOMIPRAMINE IN THE TREATMENT OF OBSESSIVE-COMPULSIVE DISORDER (OCD) AMONG CHILDREN AND ADOLESCENTS ,” HAKIM RESEARCH JOURNAL, vol. 5, no. 1, pp. 37–42, 2002, [Online]. Available: https://sid.ir/paper/29377/en

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