META-ANALYSIS OF THE RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINELEVELS AND CARBAMAZEPINE MONOTHERAPY IN PATIENTS WITH EPILEPSY

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YING YIN; LI HONGCHUN; JIN JIYE; LU XULIANG; FENG PINPIN; SUN YUNFENG

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Journal Paper

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Journal: Iranian Red Crescent Medical Journal Year:2017 | Volume:19 | Issue:11 Page(s): 0-0

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Title

META-ANALYSIS OF THE RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINELEVELS AND CARBAMAZEPINE MONOTHERAPY IN PATIENTS WITH EPILEPSY

Author(s)

Keywords

EPILEPSY

CARBAMAZEPINE

HOMOCYSTEINE

META-ANALYSIS

Abstract

Background: Numerous studies have shown that long-term treatment with anticonvulsants may be an important risk factor forthe onset of atherosclerosis, or worsening of its symptoms. Context: The present study aimed at investigating the relationship between CARBAMAZEPINE (CBZ) monotherapy and plasma HOMOCYSTEINE(Hcy) levels in patients with EPILEPSY. Evidence Acquisition: Studies concerning HOMOCYSTEINE levels in CARBAMAZEPINE monotherapy patients with EPILEPSY, which werepublished in VIP, Wanfang, CNKI, Cochrance Library, PubMed, Web of Science, and EMBASE, were included in March 2016. The qualityof the controlled clinical trials (CCT) selected for this study was assessed using the Newcastle-Ottawa scale (NOS), and the relevantdata of the included studies were extracted through RevMan5. 2 software. Results: In this META-ANALYSIS, 22 eligible studies were enrolled including 9 Chinese and 13 English studies. The study included atotal of 1604 cases including 575 cases of patient group and 1029 control group cases. Results of the META-ANALYSIS showed thatplasma HOMOCYSTEINE level in patients with EPILEPSY with long-term treatment of CBZ was significantly higher than that in thehealthy control group [SMD = 1. 55, 95% CI: [1. 09, 2. 01], P < 0. 00001]. Moreover, there was significant heterogeneity in the estimatesaccording to I2 test (P < 0. 00001; I2 = 93%). Further subgroup analysis showed that no significant difference was present when thestudy participants were grouped by region and age, however, the risk of heterogeneity in the West Asian group (I2 = 58%, P = 0. 07)was diminished when compared with overall groups (I2 = 93%, P < 0. 00001). The results of sensitivity analysis by Stata12. 0 showedgood stability. The funnel plotmethod and Beggmethodwere used to detect publication bias, and the results showed a substantiallysymmetrical funnel plot, Pr > |Z|= 0. 091 > 0. 05 (no statistical significance), suggesting no significant publication bias in the study. Loss factor of safety (Nfs) 0. 05 equaled 7269. 16 (P = 0. 05), meaning that addition of about 7269 negative results were required tooverthrow the conclusion of this study. Conclusions: The seizures significantly increased plasma HOMOCYSTEINE levels in the patients, thus it is appropriate to add folicacid, vitamin B12, and vitamin B6 to reduce the seizures. Moreover, HOMOCYSTEINE may be beneficial for those patients with EPILEPSYwho take CARBAMAZEPINE.

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APA: Copy

YING, YIN, LI, HONGCHUN, JIN, JIYE, LU, XULIANG, FENG, PINPIN, & SUN, YUNFENG. (2017). META-ANALYSIS OF THE RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINELEVELS AND CARBAMAZEPINE MONOTHERAPY IN PATIENTS WITH EPILEPSY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(11), 0-0. SID. https://sid.ir/paper/293811/en

Vancouver: Copy

YING YIN, LI HONGCHUN, JIN JIYE, LU XULIANG, FENG PINPIN, SUN YUNFENG. META-ANALYSIS OF THE RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINELEVELS AND CARBAMAZEPINE MONOTHERAPY IN PATIENTS WITH EPILEPSY. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(11):0-0. Available from: https://sid.ir/paper/293811/en

IEEE: Copy

YIN YING, HONGCHUN LI, JIYE JIN, XULIANG LU, PINPIN FENG, and YUNFENG SUN, “META-ANALYSIS OF THE RELATIONSHIP BETWEEN PLASMA HOMOCYSTEINELEVELS AND CARBAMAZEPINE MONOTHERAPY IN PATIENTS WITH EPILEPSY,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 11, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293811/en

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