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Title

EFFICACY OF VITAMIN D3 IN PATIENTS WITH DIABETIC NEPHROPATHY: ANUPDATED META-ANALYSIS

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Abstract

 Context: Diabetic nephropathy is a common complication of diabetes mellitus with a higher incidence. Renin-angiotensin systemblockers, as the main treatment for patients with diabetic kidney disease, can not only reduce albuminuria, but also lead tohyperkalaemia and creatinine. Therefore, additional protective therapeutic interventions are needed. Evidence Acquisition: An electronic literature search was conducted in international and domestic databases including PubMed, Embase, CNKI, Scopus, Index Copernicus, DOAJ, and Wanfang database for trials up to January 2017. The search terms used wereas follow: "Diabetic Nephropathies", "VITAMIN D3", "Cholecalciferol", "Calcitriol", "Alfacalcidol", "Paricalcitol", and "Randomized ControlledTrial". Quality assessments were evaluated with the Newcastle-Ottawa Quality Assessment Scale. Data were extracted by 2independent reviewers (TJL and WGL). For all analysis, the standard mean difference (SMD) or odds ratio (OR) with 95% confidenceintervals (CIs) were calculated, and heterogeneity of the studies was analyzed using I2 statistics. Results: Twenty-four studies were (1, 978 patients) identified in the literature retrieve process. The assessment scores indicated thatall the admitted studies were reliable with scores ranging from 6 to 9. The pooled results indicated that VITAMIN D3 had a significanteffect in reducing albuminuria (MD =-0. 23, 95% CI:-0. 30,-0. 15) and that the VITAMIN D3 group had a low ratio of urinary microalbuminto creatinine than the control group (SMD =-0. 49, 95% CI:-0. 90,-0. 08). The results also revealed that VITAMIN D3 group had alower hs-CRP than the control group (MD =-0. 80, 95% CI:-1. 26,-0. 34). Conclusions: Based on the evidence of this study, VITAMIN D3 could be suggested as a recommended drug for patients with diabeticnephropathy in clinical practice.

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    APA: Copy

    ZHANG, MIN, LIU, TIEJUN, LI, WENGE, GONG, WEIJUN, YANG, XUSHENG, & XI, JIANING. (2017). EFFICACY OF VITAMIN D3 IN PATIENTS WITH DIABETIC NEPHROPATHY: ANUPDATED META-ANALYSIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 19(12), 0-0. SID. https://sid.ir/paper/293833/en

    Vancouver: Copy

    ZHANG MIN, LIU TIEJUN, LI WENGE, GONG WEIJUN, YANG XUSHENG, XI JIANING. EFFICACY OF VITAMIN D3 IN PATIENTS WITH DIABETIC NEPHROPATHY: ANUPDATED META-ANALYSIS. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2017;19(12):0-0. Available from: https://sid.ir/paper/293833/en

    IEEE: Copy

    MIN ZHANG, TIEJUN LIU, WENGE LI, WEIJUN GONG, XUSHENG YANG, and JIANING XI, “EFFICACY OF VITAMIN D3 IN PATIENTS WITH DIABETIC NEPHROPATHY: ANUPDATED META-ANALYSIS,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 19, no. 12, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/293833/en

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