Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

352
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

220
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

1

Information Journal Paper

Title

The Protective Effect of Hydroalcoholic Extract of the Southern Maidenhair Fern (Adiantum capillus-veneris) on the Depression and Anxiety Caused by Chronic Stress in Adult Male Mice: An Experimental Randomized Study

Author(s)

 Ahmadpoor Jafar | Valipour Chahardahcheric Saeid | SETORKI MAHBUBEH | Issue Writer Certificate 

Pages

  0-0

Abstract

 Background: Antioxidant compounds are novel approaches in the treatment of neurological disorders. Objectives: The purpose of this study was to examine the antidepressant and anxiolytic effects of the hydroalcoholic extract of Adiantum capillus-veneris (rich in Flavonoids with antioxidant properties) in Mice under chronic restraint stress (CRS). Methods: This experimental study was conducted in a university-affiliated Experimental Animal Unit, Khuzestan, Iran, from April to June 2018. Forty male Balb/C Mice were randomly divided into five groups (n = 8), including under chronic restraint stress (CRS) receiving normal saline, hydroalcoholic extract of A. capillus-veneris (100, 200, and 400 mg/kg/day, i. p), or diazepam (10 mg/kg/day, i. p). After 21 days of the consecutive treatment, anxiolytic and antidepressant activities were evaluated using elevated plus-maze (EPM) and forced swim test (FST). Moreover, serum and brain levels of total antioxidant capacity (TAC) and malondialdehyde (MDA), as well as serum Corticosterone, were measured. Results: Immobility time in the FSTwassignificantly decreased (P=0. 002, P=0. 001, P< 0. 0001) after treatingCRSMicewith all doses of the extract. CRS-exposed Mice treated with all doses of the extract showed a significantly increased percentage of entries into the open arm (P < 0. 0001, P = 0. 001) and reduced closed arm entries in the EPM (P = 0. 012, P = 0. 024). Extract at all doses significantly increased serum (P < 0. 0001) and brain (P = 0. 011, P = 0. 004, P = 0. 001) TAC in CRS-exposed Mice. The extract (200 and 400 mg/kg) also reduced CRS-induced serum and brainMDA(P< 0. 0001, P = 0. 001). Serum Corticosterone did not significantly change following the extract treatment. Conclusions: A. capillus-veneris extract showed antidepressant and anxiolytic effects by reducing Oxidative Stress markers.

Cites

References

Cite

APA: Copy

Ahmadpoor, Jafar, Valipour Chahardahcheric, Saeid, & SETORKI, MAHBUBEH. (2019). The Protective Effect of Hydroalcoholic Extract of the Southern Maidenhair Fern (Adiantum capillus-veneris) on the Depression and Anxiety Caused by Chronic Stress in Adult Male Mice: An Experimental Randomized Study. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), 21(3), 0-0. SID. https://sid.ir/paper/293872/en

Vancouver: Copy

Ahmadpoor Jafar, Valipour Chahardahcheric Saeid, SETORKI MAHBUBEH. The Protective Effect of Hydroalcoholic Extract of the Southern Maidenhair Fern (Adiantum capillus-veneris) on the Depression and Anxiety Caused by Chronic Stress in Adult Male Mice: An Experimental Randomized Study. IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ)[Internet]. 2019;21(3):0-0. Available from: https://sid.ir/paper/293872/en

IEEE: Copy

Jafar Ahmadpoor, Saeid Valipour Chahardahcheric, and MAHBUBEH SETORKI, “The Protective Effect of Hydroalcoholic Extract of the Southern Maidenhair Fern (Adiantum capillus-veneris) on the Depression and Anxiety Caused by Chronic Stress in Adult Male Mice: An Experimental Randomized Study,” IRANIAN RED CRESCENT MEDICAL JOURNAL (IRCMJ), vol. 21, no. 3, pp. 0–0, 2019, [Online]. Available: https://sid.ir/paper/293872/en

Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top