EFFECTS OF NOVEL2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM

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HADIZADEH F.; ANARAKI FIROOZ B.F.; TAGHAVI S.I.H.

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Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2005 | Volume:18 | Issue:4 Page(s): 361-364

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Title

EFFECTS OF NOVEL2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM

Author(s)

HADIZADEH F. | ANARAKI FIROOZ B.F. | TAGHAVI S.I.H.

Keywords

2-DIMETHYLAMINO-SUBSTITUTED DIHYDROPYRIDINES

RABBIT JEJUNUM

CALCIUM CHANNEL

Abstract

In order to investigate the effects of dimethylamino substituent at position 2 of the diliydropyridine nucleus on activity, starting from dialkyl 1,4- dihydro -2,6- dimethyl -4- (1-benzyl- 2- alkylthio -5-imidazolyl) -3,5- pyridinedicarboxylates (5a-f) which their synthesis and effects as CALCIUM CHANNEL antagonist on guinea-pig ileum has been reported previously, dialkyl 1,4-diliydro-2- [2- (dimethylamino) ethyl]-6-methyl -4- (1-benzyl-2- alkylthio-5-imidazolyl) - 3,5- pyridinedicarboxylates (6a-f) were synthesized.Rabbit jejunum was used to determine the relaxant or antagonistic activity of the test compounds. The test compounds (6c-e) inhibited the spontaneous contractile activity dose-dependently and completely, while high-K+ contracted tissues were relaxed partially.

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APA: Copy

HADIZADEH, F., ANARAKI FIROOZ, B.F., & TAGHAVI, S.I.H.. (2005). EFFECTS OF NOVEL2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 18(4), 361-364. SID. https://sid.ir/paper/294124/en

Vancouver: Copy

HADIZADEH F., ANARAKI FIROOZ B.F., TAGHAVI S.I.H.. EFFECTS OF NOVEL2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2005;18(4):361-364. Available from: https://sid.ir/paper/294124/en

IEEE: Copy

F. HADIZADEH, B.F. ANARAKI FIROOZ, and S.I.H. TAGHAVI, “EFFECTS OF NOVEL2-ALKYLAMINO-SUBSTITUTED DIHYDROPYRIDINES ON RABBIT JEJUNUM,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 18, no. 4, pp. 361–364, 2005, [Online]. Available: https://sid.ir/paper/294124/en

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