CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD

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AHMADI KAZEM; SOLGUE GH.

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Journal: Medical Journal of The Islamic Republic of Iran Year:2006 | Volume:20 | Issue:2 Page(s): 52-56

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Title

CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD

Author(s)

AHMADI KAZEM | SOLGUE GH. | Issue Writer Certificate

Keywords

SULFUR MUSTARD

BAL

CYTOKINE

SERUM

IL-1BETA

IL-6

IL-9

IL-12

TGFBETA AND TNF-ALFA

Abstract

Background: CYTOKINEs play a major role in both acute and chronic inflammatory processes, including those produced by SULFUR MUSTARD. This study describes the CYTOKINE level six months after exposure to a single dose of SULFUR MUSTARD, defined by IL-1b, IL-6, IL-9, IL-12, TGFb and TNF-a. Methods: The CYTOKINE levels of Broncho-Alveolar Lavage (BAL) and sera of twenty male rats exposed to SULFUR MUSTARD were measured and compared with the control group. The rats in the test group were exposed to a single dose of sulphur mustard (inhalation) and left for up to 6 months. After six months the animals were anesthetised, blood samples were obtained from their heart using 5-mL syringes and SERUM was kept at -20°C. Their BAL was collected by lavage. BAL fluid was centrifuged and left at -20°C until assay. CYTOKINE assay was performed employing the ELISA Method (Bender Med Systems).Results: The results showed significant differences (p<0.001) between the control and exposed groups in terms of all CYTOKINE (IL-9, YIFN, TGFβ, IL-6, IL-1b, IL-12 and TNFα) productions in both the BAL fluid and SERUM. The most noticeable increase in CYTOKINE release was seen in IL-9, which was 615.93% and 321.88% for the BAL fluid and SERUM, respectively (p<0.001). After IL-9 the highest increase was demonstrated for TGF-b and IL-6 in the BAL fluid which was 200.85% and 125.50% respectively.Conclusions: From data presented here, it is possible to suggest that overproduction of IL-6, IL-9 and TGFb might be involved in the late outcome of lung injury after six months exposure to SULFUR MUSTARD.

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APA: Copy

AHMADI, KAZEM, & SOLGUE, GH.. (2006). CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 20(2), 52-56. SID. https://sid.ir/paper/294240/en

Vancouver: Copy

AHMADI KAZEM, SOLGUE GH.. CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2006;20(2):52-56. Available from: https://sid.ir/paper/294240/en

IEEE: Copy

KAZEM AHMADI, and GH. SOLGUE, “CYTOKINE PATTERN IN SERA AND BRONCHO-ALVEOLAR LAVAGE SIX MONTHS AFTER SINGLE EXPOSURE TO SULFUR MUSTARD,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 20, no. 2, pp. 52–56, 2006, [Online]. Available: https://sid.ir/paper/294240/en

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