APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS

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SABZI F.; TEYMOURI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN Year:2006 | Volume:20 | Issue:3 Page(s): 119-121

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Title

APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS

Author(s)

SABZI F. | TEYMOURI H. | Issue Writer Certificate

Keywords

CARDIAC SURGERY

APROTININ

BLOOD LOSS

Abstract

Background: Aprotinin has been used increasingly to reduce postoperative blood loss in open-heart operations; due to the potentialities for complications and high cost, it would seem reasonable to use aprotinin more selectively in small doses in the prime solution of the pump.Methods: We prospectively studied the effect of preoperative low dose aprotinin [2 million units (230mg)] on blood loss and transfusion requirements in patients undergoing cardiopulmonary bypass. One-hundred and fifty patients were randomly assigned to two groups: prophylactic low dose aprotinin (group 1) and a non-medicated control group (group 2). The two groups were comparable in all demographic and operative variables.Results: Postoperative chest tube drainage was significantly decreased in the aprotinin group compared with that in the control group (372.73 mL in group 1 and 482.2 mL in group 2, p<0.05). No significant difference was seen between the two groups in regard to transfusion requirement (p>0.05). The use of fresh frozen plasma (FFP) was significantly less in group 1 than in group 2 (469.87 mL versus 680.69 mL, p<0.05).Conclusion: Prophylactic use of low-dose aprotinin immediately before cardiopulmonary bypass reduced the need for transfusion of blood & fresh frozen plasma (FFP) during the post operative period.

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APA: Copy

SABZI, F., & TEYMOURI, H.. (2006). APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 20(3), 119-121. SID. https://sid.ir/paper/294263/en

Vancouver: Copy

SABZI F., TEYMOURI H.. APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2006;20(3):119-121. Available from: https://sid.ir/paper/294263/en

IEEE: Copy

F. SABZI, and H. TEYMOURI, “APROTININ: EFFECTS ON BLOOD LOSS AND FRESH FROZEN PLASMA REQUIREMENT IN CARDIAC OPERATIONS,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 20, no. 3, pp. 119–121, 2006, [Online]. Available: https://sid.ir/paper/294263/en

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