EPINEPHRINE SUPPRESSES SECRETION OF VLDL-ASSOIATED TRIAIATCYLYCEROL AND INCREASES TRIACYLGCEROL AND PHOSPHOLIPID CONTENTS IN ISOLATED RAT HEPATOCYTES

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RASOULI MAHDI; SHARIF M.; ZAHRAEI M.

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Journal: Medical Journal of The Islamic Republic of Iran Year:2000 | Volume:14 | Issue:1 Page(s): 61-68

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Title

EPINEPHRINE SUPPRESSES SECRETION OF VLDL-ASSOIATED TRIAIATCYLYCEROL AND INCREASES TRIACYLGCEROL AND PHOSPHOLIPID CONTENTS IN ISOLATED RAT HEPATOCYTES

Author(s)

RASOULI MAHDI | SHARIF M. | ZAHRAEI M. | Issue Writer Certificate

Keywords

EPINEPHRINE

PHOSPHOLIPID

HEPATOCYTES

TRIACYLGLYCEROL

VLDL

Abstract

The effect of EPINEPHRINE on TRIACYLGLYCEROL secretion was investigated in isolated rat HEPATOCYTES. The effect appeared at concentrations of more than 1mM and reached a plateau at 10mM. EPINEPHRINE concentration for half of the maximal bioeffect (EC50) was about 1mM. Epineplnineat a concentration of 10mM suppressed TRIACYLGLYCEROL secretion by 33%andincreasedits cellular content by approximately 18%. The total TRIACYLGLYCEROL content of the system (sum of the cell and the incubation medium) was constant at all concentrations of EPINEPHRINE. Time course experiments for TRIACYLGLYCEROL secretion exhibited relatively similar results on the basis of lipid analysis with or without lipid extractions. On the former basis TRIACYLGLYCEROL secretion versus time followed a linear relationship with a slope of 1.47±0.11 mmole TG/3h/g wet liver. Time course curves of cellular lipids revealed that cellular TRIACYLGLYCEROL and PHOSPHOLIPID contents in the presence of EPINEPHRINE were higher than the control at all time points, and the difference was constant during time. Furthermore, in the presence of glucose (20 mM) and oleate (0.25 mM), intracellular TRIACYLGLYCEROL content increased markedly (³45%) whereas cellular PHOSPHOLIPID content remained constant. It is proposed that EPINEPHRINE exerts an inhibitory effect on VLDL secretion probably through blocking in the secretary pathway.

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APA: Copy

RASOULI, MAHDI, SHARIF, M., & ZAHRAEI, M.. (2000). EPINEPHRINE SUPPRESSES SECRETION OF VLDL-ASSOIATED TRIAIATCYLYCEROL AND INCREASES TRIACYLGCEROL AND PHOSPHOLIPID CONTENTS IN ISOLATED RAT HEPATOCYTES. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 14(1), 61-68. SID. https://sid.ir/paper/294300/en

Vancouver: Copy

RASOULI MAHDI, SHARIF M., ZAHRAEI M.. EPINEPHRINE SUPPRESSES SECRETION OF VLDL-ASSOIATED TRIAIATCYLYCEROL AND INCREASES TRIACYLGCEROL AND PHOSPHOLIPID CONTENTS IN ISOLATED RAT HEPATOCYTES. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2000;14(1):61-68. Available from: https://sid.ir/paper/294300/en

IEEE: Copy

MAHDI RASOULI, M. SHARIF, and M. ZAHRAEI, “EPINEPHRINE SUPPRESSES SECRETION OF VLDL-ASSOIATED TRIAIATCYLYCEROL AND INCREASES TRIACYLGCEROL AND PHOSPHOLIPID CONTENTS IN ISOLATED RAT HEPATOCYTES,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 14, no. 1, pp. 61–68, 2000, [Online]. Available: https://sid.ir/paper/294300/en

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