THE ASSOCIATION BETWEEN SMALL DENSE LOW DENSITY LIPOPROTEIN, APOLIPOPROTEIN B, APOLIPOPROTEIN B/APOLIPOPROTEIN A1 RATIO AND CORONARY ARTERY STENOSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HOSSEINI GOHARI LADAN; KARIMZADEH GHASSAB ROMINA; FIROOZRAY MOHSEN; ZAVAREHEE ABBAS; BASIRI HOSSEIN ALI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2009 | Volume:23 | Issue:1 Page(s): 8-13

Download Full-Text

View:

344

Download:

143

Cites:

Information Journal Paper

Title

THE ASSOCIATION BETWEEN SMALL DENSE LOW DENSITY LIPOPROTEIN, APOLIPOPROTEIN B, APOLIPOPROTEIN B/APOLIPOPROTEIN A1 RATIO AND CORONARY ARTERY STENOSIS

Author(s)

Keywords

SMALL DENSE LDL

APOLIPOPROTEIN

CORONARY ARTERY DISEASE

Abstract

Background: Recently, small dense low density lipoprotein (sdLDL) has been highlighted as a new risk factor for the CORONARY ARTERY DISEASE (CAD).SMALL DENSE LDLs are believed to be atherogenic since these particles are taken up more easily by arterial wall. They are readily oxidized and have reduced affinity for low density lipoprotein (LDL) receptor and increased affinity for arterial proteoglicans. LDL cholesterol is only a measure of the cholesterol level in the LDL whereas APOLIPOPROTEIN B (apo B) is a measure of the cholesterol levels of all the atherogenic particles, including very low density lipoprotein, intermediate density, and low density lipoproteins.Therefore, it might be a better marker than other traditional lipids. The aim of the present study was to evaluate the association between serum SMALL DENSE LDL, APOLIPOPROTEIN B, APOLIPOPROTEIN A1 (apo A1) and apoB/apoA1 ratio and the coronary stenosis.Methods: 86 patients with coronary stenosis, 35 patients without coronary stenosis identified by angiography who were referred to Rajaii Heart Center, and 30 healthy individuals were studied. SdLDL was measured by a direct homogenous LDL-C assay in the supernatant of serum which remained after heparin-magnesium precipitation. Serum APOLIPOPROTEIN A1 and APOLIPOPROTEIN B were measured by using immunoturbidimetric method.Results: The results showed that the sdLDL levels were higher in patients with coronary stenosis than patients without coronary stenosis and healthy individuals (21.54±7.1, 16.88±4.4 and 15.45±5mg/dl, p=0.001, respectively). In addition the level of apoB (with stenosis: 113.71±21.8, without stenosis: 100.88±18.7 and healthy: 102.30±9.6, p=0.003) and apoB/apoA1 ratio (with stenosis: 1.100±0.24, without stenosis: 0.589±0.26 and healthy: 0.751±0.16, p=0.001) were significantly higher in patients with coronary stenosis. SdLDL levels were positively correlated with the level of apoB (r=0.589), apoB/apoA1 ratio (r=0.416), triglyceride (r=0.494), LDL-C (r=0.749), Total cholesterol (r=0.354) and were inversely correlated with the level of HDL-C (r=-0.586) (p<0.01).Conclusion: The elevated levels of SMALL DENSE LDL, apoB and apoB/apoA1 ratio were associated with coronary artery stenosis.

Cites

No record.

References

No record.

Cite

APA: Copy

HOSSEINI GOHARI, LADAN, KARIMZADEH GHASSAB, ROMINA, FIROOZRAY, MOHSEN, ZAVAREHEE, ABBAS, & BASIRI, HOSSEIN ALI. (2009). THE ASSOCIATION BETWEEN SMALL DENSE LOW DENSITY LIPOPROTEIN, APOLIPOPROTEIN B, APOLIPOPROTEIN B/APOLIPOPROTEIN A1 RATIO AND CORONARY ARTERY STENOSIS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 23(1), 8-13. SID. https://sid.ir/paper/294422/en

Vancouver: Copy

HOSSEINI GOHARI LADAN, KARIMZADEH GHASSAB ROMINA, FIROOZRAY MOHSEN, ZAVAREHEE ABBAS, BASIRI HOSSEIN ALI. THE ASSOCIATION BETWEEN SMALL DENSE LOW DENSITY LIPOPROTEIN, APOLIPOPROTEIN B, APOLIPOPROTEIN B/APOLIPOPROTEIN A1 RATIO AND CORONARY ARTERY STENOSIS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2009;23(1):8-13. Available from: https://sid.ir/paper/294422/en

IEEE: Copy

LADAN HOSSEINI GOHARI, ROMINA KARIMZADEH GHASSAB, MOHSEN FIROOZRAY, ABBAS ZAVAREHEE, and HOSSEIN ALI BASIRI, “THE ASSOCIATION BETWEEN SMALL DENSE LOW DENSITY LIPOPROTEIN, APOLIPOPROTEIN B, APOLIPOPROTEIN B/APOLIPOPROTEIN A1 RATIO AND CORONARY ARTERY STENOSIS,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 23, no. 1, pp. 8–13, 2009, [Online]. Available: https://sid.ir/paper/294422/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops