CORRELATION BETWEEN URINE MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)/CREATININE RATIO AND TIME AFTER KIDNEY TRANSPLANTATION

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OTUKESH HASAN; FERESHTEHNEJAD SEYED MOHAMMAD; HOSEINI ROZITA; CHALIAN MAJID; BEDAYAT ARASH; SALMAN YAZDI REZA; SAFARZADEH AMIR EBRAHIM; SABAGHI SAEED; MAHDAVI SAEED

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Journal: Medical Journal of The Islamic Republic of Iran Year:2008 | Volume:22 | Issue:2 Page(s): 55-62

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Title

CORRELATION BETWEEN URINE MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)/CREATININE RATIO AND TIME AFTER KIDNEY TRANSPLANTATION

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Keywords

CHRONIC ALLOGRAFT NEPHROPATHY

MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)

CREATININE

TRANSPLANTATION

Abstract

Background: Despite the long-standing association of macrophage migration inhibitory factor (MIF) with delayed-type hypersensitivity response, the potential role of MIF in CHRONIC ALLOGRAFT NEPHROPATHY is unknown. The association between upregulation of MIF expression, macrophage and T cell infiltration and the severity of CHRONIC ALLOGRAFT NEPHROPATHY suggests that MIF may be an important mediator in the process of CHRONIC ALLOGRAFT NEPHROPATHY. Therefore, the aims of this study were to measure urine concentration of MIF after renal TRANSPLANTATION, and to determine if it increases with time.Methods: In this prospective cross-sectional study twenty-two pediatric patients (case, group A) who received kidney transplants between 1999 and 2006, and forty healthy children (control, group B) were recruited. Urine MIF and CREATININE were assessed in all patients. Urine MIF concentrations were quantitated by ELISA.Results: The mean ratios of urine MIF/Creatinine (Cr) were calculated as 5.046 (SEM=2.04) pg/mmol CREATININE in transplanted-kidney patients (group A) and 1.85 (SEM=0.35) pg/mmol CREATININE in healthy individuals (group B). Agood significant correlation was seen between urine MIF/Cr ratio and time after kidney TRANSPLANTATION in recipients (P=0.002, rSpearman=+0.633).Conclusion: This study shows significant correlation between urine MIF/Cr ratio and time passed after TRANSPLANTATION. Increasing MIF/Cr ratios were seen in patients with a longer post TRANSPLANTATION period. Therefore, it is necessary to determine the role of macrophages in chronic renal nephropathy especially chronic rejection with additive studies and then study the effect of anti-MIF antibodies in the treatment of this condition.

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APA: Copy

OTUKESH, HASAN, FERESHTEHNEJAD, SEYED MOHAMMAD, HOSEINI, ROZITA, CHALIAN, MAJID, BEDAYAT, ARASH, SALMAN YAZDI, REZA, SAFARZADEH, AMIR EBRAHIM, SABAGHI, SAEED, & MAHDAVI, SAEED. (2008). CORRELATION BETWEEN URINE MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)/CREATININE RATIO AND TIME AFTER KIDNEY TRANSPLANTATION. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 22(2), 55-62. SID. https://sid.ir/paper/294450/en

Vancouver: Copy

OTUKESH HASAN, FERESHTEHNEJAD SEYED MOHAMMAD, HOSEINI ROZITA, CHALIAN MAJID, BEDAYAT ARASH, SALMAN YAZDI REZA, SAFARZADEH AMIR EBRAHIM, SABAGHI SAEED, MAHDAVI SAEED. CORRELATION BETWEEN URINE MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)/CREATININE RATIO AND TIME AFTER KIDNEY TRANSPLANTATION. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2008;22(2):55-62. Available from: https://sid.ir/paper/294450/en

IEEE: Copy

HASAN OTUKESH, SEYED MOHAMMAD FERESHTEHNEJAD, ROZITA HOSEINI, MAJID CHALIAN, ARASH BEDAYAT, REZA SALMAN YAZDI, AMIR EBRAHIM SAFARZADEH, SAEED SABAGHI, and SAEED MAHDAVI, “CORRELATION BETWEEN URINE MACROPHAGE MIGRATION INHIBITORY FACTOR (MIF)/CREATININE RATIO AND TIME AFTER KIDNEY TRANSPLANTATION,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 22, no. 2, pp. 55–62, 2008, [Online]. Available: https://sid.ir/paper/294450/en

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