NOSCAPINE ANTAGONIZES VASOCONSTRICTOR ACTION OF BRADYKININ IN ISOLATED HUMAN UMBILICAL ARTERY

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MAHMOUDIAN MASSOUD; ABOUTALEB NAHID; BEIRANVAND FARAHNAZ; MOAZZAM ASHRAF ALSADAT; SHAFIEI MASSOUMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Journal of The Islamic Republic of Iran Year:2011 | Volume:25 | Issue:2 Page(s): 82-86

Download Full-Text

View:

318

Download:

129

Cites:

Information Journal Paper

Title

NOSCAPINE ANTAGONIZES VASOCONSTRICTOR ACTION OF BRADYKININ IN ISOLATED HUMAN UMBILICAL ARTERY

Author(s)

Keywords

NOSCAPINE

HUMAN UMBILICAL ARTERY

BRADYKININ

HISTAMINE

Abstract

Background: It has been demonstrated that NOSCAPINE, an antitussive opioid alkaloid, could antagonize BRADYKININ- induced responses such as BRADYKININ effects in guinea-pig ileum, cough induced by BRADYKININ receptor agonist and angiotensin converting enzyme inhibitors, and brain damage after brain edema both in neonatal rat model and in patients with stroke. In the present study, the effect of NOSCAPINE on BRADYKININ-induced constriction of HUMAN UMBILICAL ARTERY was investigated.Methods: Segments of human umbilical cords were obtained from women with normal full term pregnancies. Concentration-response curves for BRADYKININ (1-1000 nM) were constructed in the absence and presence of NOSCAPINE (1-1000 nM). To show the specificity of NOSCAPINE for BRADYKININ-induced constriction in the tissue, the effect of NOSCAPINE (10 pM) on vasoconstriction produced by HISTAMINE were also examined.Results: The results showed that NOSCAPINE could antagonize the constriction produced by BRADYKININ in HUMAN UMBILICAL ARTERY. It was also demonstrated that NOSCAPINE was capable of reducing HISTAMINE-induced contractile response.Conclusion: It is concluded that NOSCAPINE can antagonize BRADYKININ-induced constriction of HUMAN UMBILICAL ARTERY in a nonspecific manner. Thus, NOSCAPINE is likely to find a clinical application in pathologic conditions accompanied by higher vascular sensitivity to BRADYKININ in pregnancy.

Cites

No record.

References

No record.

Cite

APA: Copy

MAHMOUDIAN, MASSOUD, ABOUTALEB, NAHID, BEIRANVAND, FARAHNAZ, MOAZZAM, ASHRAF ALSADAT, & SHAFIEI, MASSOUMEH. (2011). NOSCAPINE ANTAGONIZES VASOCONSTRICTOR ACTION OF BRADYKININ IN ISOLATED HUMAN UMBILICAL ARTERY. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 25(2), 82-86. SID. https://sid.ir/paper/294472/en

Vancouver: Copy

MAHMOUDIAN MASSOUD, ABOUTALEB NAHID, BEIRANVAND FARAHNAZ, MOAZZAM ASHRAF ALSADAT, SHAFIEI MASSOUMEH. NOSCAPINE ANTAGONIZES VASOCONSTRICTOR ACTION OF BRADYKININ IN ISOLATED HUMAN UMBILICAL ARTERY. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2011;25(2):82-86. Available from: https://sid.ir/paper/294472/en

IEEE: Copy

MASSOUD MAHMOUDIAN, NAHID ABOUTALEB, FARAHNAZ BEIRANVAND, ASHRAF ALSADAT MOAZZAM, and MASSOUMEH SHAFIEI, “NOSCAPINE ANTAGONIZES VASOCONSTRICTOR ACTION OF BRADYKININ IN ISOLATED HUMAN UMBILICAL ARTERY,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 25, no. 2, pp. 82–86, 2011, [Online]. Available: https://sid.ir/paper/294472/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops