THE EFFECT OF DEPRESSION AND ANXIETY ON EXPRESSION LEVELS OF TOLL LIKE RECEPTOR SIGNALING MOLECULES IN CHRONIC HBV INFECTED PATIENTS

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NIKBAKHT DASTJERDI MEHDI; MOMENI MOHAMMAD

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Journal Paper

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Journal: Medical Journal of The Islamic Republic of Iran Year:2015 | Volume:29 | Issue:1 Page(s): 0-0

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Title

THE EFFECT OF DEPRESSION AND ANXIETY ON EXPRESSION LEVELS OF TOLL LIKE RECEPTOR SIGNALING MOLECULES IN CHRONIC HBV INFECTED PATIENTS

Author(s)

NIKBAKHT DASTJERDI MEHDI | MOMENI MOHAMMAD | Issue Writer Certificate

Keywords

DEPRESSION

ANXIETY

CHRONIC HBV INFECTION

IRAK4

TRAF3

IRF7

Abstract

Background: Toll- like receptors (TLRs) play an important role in the recognition of DAMPs and PAMPs and induction of inflammation. Previous studies demonstrated that DEPRESSION and ANXIETY can influence the expression levels of immune related molecules. Our previous study revealed that mRNA levels of IRAKIRAK4, TRAF3 and IRF7 were significantly decreased in chronic HBV infected (CHB) patients when compared to healthy controls. Therefore, the aim of this study was to evaluate the effects of DEPRESSION and ANXIETY on the expression levels of these molecules in CHB patients.Methods: Sixty CHB patients participated in this study and filled out the standard questionnaires; and the expression of IRAK4, TRAF3 and IRF7 were examined using Real-Time PCR techniques.Results: The results of this study demonstrated that expression of IRAK4, TRAF3 and IRF7 did not differ between patients with various stages of DEPRESSION and ANXIETY (all p>0.05).Conclusion: According to the results, it seems that declined expression of IRAK4, TRAF3 and IRF7 in CHB patients were not related to DEPRESSION and ANXIETY, and other factors including genetic and immunoregulatory effects of HBV may be responsible for the declined expression of these molecules.

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APA: Copy

NIKBAKHT DASTJERDI, MEHDI, & MOMENI, MOHAMMAD. (2015). THE EFFECT OF DEPRESSION AND ANXIETY ON EXPRESSION LEVELS OF TOLL LIKE RECEPTOR SIGNALING MOLECULES IN CHRONIC HBV INFECTED PATIENTS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 29(1), 0-0. SID. https://sid.ir/paper/294671/en

Vancouver: Copy

NIKBAKHT DASTJERDI MEHDI, MOMENI MOHAMMAD. THE EFFECT OF DEPRESSION AND ANXIETY ON EXPRESSION LEVELS OF TOLL LIKE RECEPTOR SIGNALING MOLECULES IN CHRONIC HBV INFECTED PATIENTS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2015;29(1):0-0. Available from: https://sid.ir/paper/294671/en

IEEE: Copy

MEHDI NIKBAKHT DASTJERDI, and MOHAMMAD MOMENI, “THE EFFECT OF DEPRESSION AND ANXIETY ON EXPRESSION LEVELS OF TOLL LIKE RECEPTOR SIGNALING MOLECULES IN CHRONIC HBV INFECTED PATIENTS,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 29, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/294671/en

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