EFFECT OF COENZYME Q10 SUPPLEMENTATION ON EXERCISE-INDUCED RESPONSE OF INFLAMMATORY INDICATORS AND BLOOD LACTATE IN MALE RUNNERS

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ARMANFAR MOSTAFA; JAFARI AFSHAR; DEHGHAN GHOLAMREZA; Abdizadeh Leila

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Journal Paper

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Journal: Medical Journal of The Islamic Republic of Iran Year:2015 | Volume:29 | Issue:1 Page(s): 0-0

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Title

EFFECT OF COENZYME Q10 SUPPLEMENTATION ON EXERCISE-INDUCED RESPONSE OF INFLAMMATORY INDICATORS AND BLOOD LACTATE IN MALE RUNNERS

Author(s)

ARMANFAR MOSTAFA | JAFARI AFSHAR | DEHGHAN GHOLAMREZA | Abdizadeh Leila | Issue Writer Certificate

Keywords

RUNNERS

COENZYME Q10

INFLAMMATORY

LACTATE

MUSCLE DAMAGE

Abstract

Background: Heavy exercise cause MUSCLE DAMAGE associated with production of INFLAMMATORY agents. The purpose of present study was to determine the effect of acute and 14-day COENZYME Q10 supplementation on INFLAMMATORY, blood LACTATE and MUSCLE DAMAGE in male middle-distance RUNNERS.Methods: Eighteen male middle-distance RUNNERS in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, COENZYME Q10: 5mg/kg/day) and placebo group (n=9, Dextrose: 5mg/kg/day). After acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). Blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. LACTATE, serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), C-reactive protein (CRP) and creatine kinase (CK) were analyzed. Repeated ANOVA and Bonferuni as a post hoc tests were used to determine the changes in four stages. Differences between groups were determined by t-test.Results: The results showed that acute and short-term COENZYME Q10 supplementation had not significant effect on basal parameters. The acute COENZYME Q10 supplementation attenuated only the exercise-induced increase in response of the plasma CRP. The short-term (14-day) COENZYME Q10 supplementation attenuated the exercise-induced increase in response of the LACTATE, serum interleukin-6, tumor necrosis factor-alpha, and CRP in male middle-distance RUNNERS. However, the acute and short-term COENZYME Q10 supplementation had not any significant effect on the exerciseinduced increase response of total serum creatine kinase.Conclusion: Based on the present results, it can be concluded that the 14-day COENZYME Q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, INFLAMMATORY and biochemical parameters.Therefore, short-term COENZYME Q10 supplementation is recommended to reduce exercise-induced adverse consequences.

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APA: Copy

ARMANFAR, MOSTAFA, JAFARI, AFSHAR, DEHGHAN, GHOLAMREZA, & Abdizadeh, Leila. (2015). EFFECT OF COENZYME Q10 SUPPLEMENTATION ON EXERCISE-INDUCED RESPONSE OF INFLAMMATORY INDICATORS AND BLOOD LACTATE IN MALE RUNNERS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 29(1), 0-0. SID. https://sid.ir/paper/294718/en

Vancouver: Copy

ARMANFAR MOSTAFA, JAFARI AFSHAR, DEHGHAN GHOLAMREZA, Abdizadeh Leila. EFFECT OF COENZYME Q10 SUPPLEMENTATION ON EXERCISE-INDUCED RESPONSE OF INFLAMMATORY INDICATORS AND BLOOD LACTATE IN MALE RUNNERS. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2015;29(1):0-0. Available from: https://sid.ir/paper/294718/en

IEEE: Copy

MOSTAFA ARMANFAR, AFSHAR JAFARI, GHOLAMREZA DEHGHAN, and Leila Abdizadeh, “EFFECT OF COENZYME Q10 SUPPLEMENTATION ON EXERCISE-INDUCED RESPONSE OF INFLAMMATORY INDICATORS AND BLOOD LACTATE IN MALE RUNNERS,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 29, no. 1, pp. 0–0, 2015, [Online]. Available: https://sid.ir/paper/294718/en

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