The effect of 3, 4-methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats

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SOLEIMANI ASL SARA; HESAM SHARIATI MOHAMAD BAKHTIAR; MEDIZADEH MEHDI; AHMADPANAH MOHAMMAD; SOHRABI MARYAM

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Journal: MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN Year:2017 | Volume:31 | Issue:1 Page(s): 0-0

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Title

The effect of 3, 4-methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats

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Keywords

Ecstasy

BDNF

Trk-β

NT4

Abstract

Background: 3, 4-methylenedioxymethamphetamine (MDMA) is a chemical derivative of amphetamine that can induce learning and memory impairment. Due to the effect of neurotrophins on memory and learning, the impact of MDMA was evaluated on the brain-derived neurotrophic factor (BDNF), neurotrophin-4 (NT-4), and tropomyosin-related kinase B (Trk-β ) expression in the hippocampus. Methods: In this study, 20 adult male Wistar rats (200-250 g) received saline (1 mL) or 10 mg/kg of MDMA intraperitoneally as single or multiple injection for 2 consecutive days per week for 2 months. Expression of BDNF, Trk-β , and NT4 were assessed using Western blotting and RT PCR methods. Results: Our results revealed that the expression of BDNF, Trk-β , and NT4 proteins and genes significantly decreased in MDMA groups compared to the sham group (p<0. 05). Furthermore, the acute group showed the lowest expression of these proteins. Conclusion: The results of the present study suggest that ecstasy administration may downregulate the expression of BDNF, Trk-β , and NT-4 in hippocampus, which is more extensive in case of acute treatment. It seems that in the chronic group, hippocampus was able to compensate the ecstasy-induced neurotoxicity.

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APA: Copy

SOLEIMANI ASL, SARA, HESAM SHARIATI, MOHAMAD BAKHTIAR, MEDIZADEH, MEHDI, AHMADPANAH, MOHAMMAD, & SOHRABI, MARYAM. (2017). The effect of 3, 4-methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), 31(1), 0-0. SID. https://sid.ir/paper/294813/en

Vancouver: Copy

SOLEIMANI ASL SARA, HESAM SHARIATI MOHAMAD BAKHTIAR, MEDIZADEH MEHDI, AHMADPANAH MOHAMMAD, SOHRABI MARYAM. The effect of 3, 4-methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats. MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI)[Internet]. 2017;31(1):0-0. Available from: https://sid.ir/paper/294813/en

IEEE: Copy

SARA SOLEIMANI ASL, MOHAMAD BAKHTIAR HESAM SHARIATI, MEHDI MEDIZADEH, MOHAMMAD AHMADPANAH, and MARYAM SOHRABI, “The effect of 3, 4-methylenedioxymethamphetamine on expression of neurotrophic factors in hippocampus of male rats,” MEDICAL JOURNAL OF THE ISLAMIC REPUBLIC OF IRAN (MJIRI), vol. 31, no. 1, pp. 0–0, 2017, [Online]. Available: https://sid.ir/paper/294813/en

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