HISTOLOGIC AND STERIOLOGIC STUDY OF OVARY AFTER THE ADMINISTRATION OF DIFFERENT DOSES OF 
CYCLOPHOSPHAMIDE

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ROUSHANGAR L.; SOLEYMANIRAD J.; HASANPOUR S.

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2009 | Volume:7 | Issue:SUPPL 1 Page(s): 0-0

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Title

HISTOLOGIC AND STERIOLOGIC STUDY OF OVARY AFTER THE ADMINISTRATION OF DIFFERENT DOSES OF CYCLOPHOSPHAMIDE

Author(s)

ROUSHANGAR L. | SOLEYMANIRAD J. | HASANPOUR S.

Keywords

OVARY

CYCLOPHOSPHAMIDE

CANCER

Abstract

Introduction: Anticancer drugs insert their effect through inhibiting cell division or inducing apoptosis. Since cell proliferation is involved in folliculogenesis, one of the side effects of anticancer drugs is disturbing folliculogenesis. The aim of the present study is to investigate the effect of different doses of CYCLOPHOSPHAMIDE on folliculogenesis of adult female mice.Materials and Methods: In the present study, 40 female Balb/c mice, aging 6-8 weeks, were used. The mice in 3 experimental groups received 15 injections of CYCLOPHOSPHAMIDE as 0.3 mg/day, 0.6 mg/day, and 0.9 mg/day. The mice in control group only received the solvent. 15 days after last injection, the animals were sacrificed and ovarian specimens were processed for light microscopy. The serial sections were stained with HandE and studied with light microscope. The stereologic study was carried out using a computerized microscope and Motic software. The data were statistically analyzed using ANOVA.Results: Histological studies showed that the number of corpora lutea and follicles at different developmental phases decreased in experimental groups in comparison to control group. Histomorphometric and stereologic studies showed that the mean number of preantral follicles in an OVARY of control group was 142±8.6 and in experimental groups 1, 2 and 3 were 104±10.7, 76.6±8.5 and 42.4±6.5, respectively, which was significantly different from the control (p<0.05). The number of antral follicles in control group was 52.6±10.7 and in experimental groups (1, 2 and 3) were 22.5±5.4, 10±2.6 and 3.2±1.8, respectively, which was significantly different from control (p<0.05).Conclusion: According to the data obtained in the present study, the daily doses of 0.3-0.9 mg CYCLOPHOSPHAMIDE for two weeks, cause reduction in follicular number and ovulation in a dose dependent manner.

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APA: Copy

ROUSHANGAR, L., SOLEYMANIRAD, J., & HASANPOUR, S.. (2009). HISTOLOGIC AND STERIOLOGIC STUDY OF OVARY AFTER THE ADMINISTRATION OF DIFFERENT DOSES OF CYCLOPHOSPHAMIDE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 7(SUPPL 1), 0-0. SID. https://sid.ir/paper/295316/en

Vancouver: Copy

ROUSHANGAR L., SOLEYMANIRAD J., HASANPOUR S.. HISTOLOGIC AND STERIOLOGIC STUDY OF OVARY AFTER THE ADMINISTRATION OF DIFFERENT DOSES OF CYCLOPHOSPHAMIDE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2009;7(SUPPL 1):0-0. Available from: https://sid.ir/paper/295316/en

IEEE: Copy

L. ROUSHANGAR, J. SOLEYMANIRAD, and S. HASANPOUR, “HISTOLOGIC AND STERIOLOGIC STUDY OF OVARY AFTER THE ADMINISTRATION OF DIFFERENT DOSES OF CYCLOPHOSPHAMIDE,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 7, no. SUPPL 1, pp. 0–0, 2009, [Online]. Available: https://sid.ir/paper/295316/en

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