PREVALENCE OF FACTOR XIII DEFICIENCY AND ABNORMAL CLOT SOLUBILITY TEST IN SISTAN AND BALUCHESTAN PROVINCE, IRAN

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ESHGHI P.; ABOU ALGHASEMI H.; SANEI MOGHADAM E.; JAZEBI M.; AMID A.

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Journal: HAKIM RESEARCH JOURNAL Year:2004 | Volume:6 | Issue:4 Page(s): 29-34

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Title

PREVALENCE OF FACTOR XIII DEFICIENCY AND ABNORMAL CLOT SOLUBILITY TEST IN SISTAN AND BALUCHESTAN PROVINCE, IRAN

Author(s)

Keywords

FACTOR XIII DEFICIENCYQ4

PREVALENCEQ2

BLEEDING DISORDERSQ4

DELAYED UMBILICAL BLEEDINGQ4

INTRACRANIAL BLEEDINGQ4

RECURRENT ABORTIONSQ4

SISTAN AND BALUCHESTANQ4

Abstract

Introduction: FACTOR XIII DEFICIENCY is a very rare bleeding disorder. Its PREVALENCE is estimated to be 1 in 1-2 million. This study was carried out to measure the PREVALENCE of deficiency and its clinical picture in SISTAN AND BALUCHESTAN province with a population of 1.5 million and a very high rate of consanguinity.Methods: During 1997-2002 all patients admitted in or referred to our hospital (which is the only center in the province with sub-specialty for BLEEDING DISORDERS) with bleeding complaints, delayed wound healing, DELAYED UMBILICAL BLEEDING or RECURRENT ABORTIONS and had normal routine coagulation tests, were screened by clot solubility test (1% monochloroacetic acid). Since 2001 the diagnosis has confirmed by measurement of plasma factor XIII levels.Results: We were able to detect 44 patients with abnormal clot solubility tests; among them, we performed factor XIII level measurement in 13 patients, which all had low factor XIII levels. Most common symptoms were DELAYED UMBILICAL BLEEDING (84%) echymosis and hematoma (69%) and delayed wound healing (66%). INTRACRANIAL BLEEDING occurred in 4 patients with abnormal clot solubility, resulted in 1 case of death and another case of hemiplegia. There was no patient referred for RECURRENT ABORTIONS.Conclusion: The PREVALENCE of FACTOR XIII DEFICIENCY is very high in this area and is the second most common congenital bleeding disorder related to coagulation factor deficiencies in this province (17%). DNA analysis studies are needed to explain this finding.

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APA: Copy

ESHGHI, P., ABOU ALGHASEMI, H., SANEI MOGHADAM, E., JAZEBI, M., & AMID, A.. (2004). PREVALENCE OF FACTOR XIII DEFICIENCY AND ABNORMAL CLOT SOLUBILITY TEST IN SISTAN AND BALUCHESTAN PROVINCE, IRAN. HAKIM RESEARCH JOURNAL, 6(4), 29-34. SID. https://sid.ir/paper/29532/en

Vancouver: Copy

ESHGHI P., ABOU ALGHASEMI H., SANEI MOGHADAM E., JAZEBI M., AMID A.. PREVALENCE OF FACTOR XIII DEFICIENCY AND ABNORMAL CLOT SOLUBILITY TEST IN SISTAN AND BALUCHESTAN PROVINCE, IRAN. HAKIM RESEARCH JOURNAL[Internet]. 2004;6(4):29-34. Available from: https://sid.ir/paper/29532/en

IEEE: Copy

P. ESHGHI, H. ABOU ALGHASEMI, E. SANEI MOGHADAM, M. JAZEBI, and A. AMID, “PREVALENCE OF FACTOR XIII DEFICIENCY AND ABNORMAL CLOT SOLUBILITY TEST IN SISTAN AND BALUCHESTAN PROVINCE, IRAN,” HAKIM RESEARCH JOURNAL, vol. 6, no. 4, pp. 29–34, 2004, [Online]. Available: https://sid.ir/paper/29532/en

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