Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

753
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

497
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

3

Information Journal Paper

Title

THE EFFECTS OF DIAZINON ON TESTOSTERONE, FSH AND LH LEVELS AND TESTICULAR TISSUE IN MICE

Pages

  59-64

Abstract

 Background: DIAZINON (DZN) is an organophosphate insecticide which is used worldwide in agriculture. The exposure to this chemical might lead to damages to the living systems.Objective: The present study was done to investigate the effects of DIAZINON on the structure of testis and levels of sex hormones in adult male mice.Materials and Methods: For this experiment, the mature male mice divided into three groups; Control (no injection), sham (corn oil injection) and DZN (DIAZINON was administrated at dose of 30 mg / kg for 30 d five consecutive days per week). Animals were killed 35 days after the latest injection. Testes tissues sections were provided to investigate the histopathological changes. Serum TESTOSTERONE, LH and FSH concentrations were measured by radioimmunoassay. Data were analyzed using of oneway ANOVA. Significance was set at p<0.05.Results: A significant reduction was observed in diameter and weight of testes after DZN administration. Furthermore, DZN brought about significant reduction in sperm counts and spermatogenic, Leydig and Sertoli cells and a decrease in serum TESTOSTERONE concentration. Histopathological examination of testes showed degenerative changes in seminiferous tubules (p<0.001). The levels of LH and FSH were increased in DZN groups compared to the control and sham groups (p<0.05).Conclusion: DZN is a toxicant for mammals’ spermatogenic cells during the early spermatogenesis. Therefore, application of DZN should be limited to a designed program.

Cites

References

  • No record.

    • Cite

    APA: Copy

    FATAHI, ESMAEIL, PARIVAR, KAZEM, JOURSARAEI, S.GH.A., & MOGHADAMNIA, ALI AKBAR. (2009). THE EFFECTS OF DIAZINON ON TESTOSTERONE, FSH AND LH LEVELS AND TESTICULAR TISSUE IN MICE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 7(2), 59-64. SID. https://sid.ir/paper/295339/en

    Vancouver: Copy

    FATAHI ESMAEIL, PARIVAR KAZEM, JOURSARAEI S.GH.A., MOGHADAMNIA ALI AKBAR. THE EFFECTS OF DIAZINON ON TESTOSTERONE, FSH AND LH LEVELS AND TESTICULAR TISSUE IN MICE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2009;7(2):59-64. Available from: https://sid.ir/paper/295339/en

    IEEE: Copy

    ESMAEIL FATAHI, KAZEM PARIVAR, S.GH.A. JOURSARAEI, and ALI AKBAR MOGHADAMNIA, “THE EFFECTS OF DIAZINON ON TESTOSTERONE, FSH AND LH LEVELS AND TESTICULAR TISSUE IN MICE,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 7, no. 2, pp. 59–64, 2009, [Online]. Available: https://sid.ir/paper/295339/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top