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Title

APPLICATION OF ALOE GEL FORMULATION IN RADIOTHERAPEUTIC DAMAGE CAUSED BY GAMMA- RAY

Pages

  274-280

Abstract

 Many investigators all around the world are working to find the best and novel methods for CANCER treatment. Among them some are trying to reduce the treatment side effects from which patients are suffering.The side effects of Gamma-Ray on skin appear in forms of different damages, including. erythema, dry desquamation, wet desquamation and even skin necrosis and wounds. At present to prevent such damages some external oil- riched creams and ointments including Zinc Oxide are used which are not appear to be very useful. Fortunately there are extensive information's about ALOE plant and it's good effects on burn, skin wounds, healing, anti-inflammation and sunbrun which facilitate the use of this new formulated medicinal plant in modern medicine. Because of skin protection ability of the plant extract against the sunburn it was suggested by the present workers that it may also protect the skin from Gamma ray due to RADIOTHERAPY. According to British Pharmacopoeia (B.P.) the most effective and active substances of the (ALOE VERA) are barbaloin and Aloin with the chemical base of hydroxyanthracene that have incompatibility with alkalines. This study was conducted in one of the best CANCER centers (Tajrish Shohada hospital), 70 patients were randomly selected and divided in four groups of test (2) and control (2). ALOE extract in form of GEL FORMULATION as the best preparation was chosen and applied. The test groups (35 patients) were treated by ALOE Gel either along with RADIOTHERAPY program, or right after RADIOTHERAPY treatment completed. For control groups (35 patients) after each RADIOTHERAPY program, either Zinc Oxide cream was applied or no treatment conducted. The irradiation equipment was cobalt 60, and the average irradiation rays was 180-200 centigray/day. all the 70 patients had different forms of CANCERs. For this reason the principal variables of the study were chosen "Healing effectiveness" and "Tissue damage rate". The results and comparison between test and control groups indicated that: a- The overall effectiveness in test groups are much higher than control groups.b- The healing in test groups compare to control groups is significant (p<0.05).c- The average healing period (AHP)) for the group which using GEL FORMULATION right after RADIOTHERAPY started or after total period completed were significantly shorter than the group that was treated by Zinc Oxide (p<0.001).For the best result achievement it is highly recommended that for CANCER RADIOTHERAPY treatment, ALOE GEL FORMULATION be applied because of its preventive effect on skin from the beginning up to the end of the RADIOTHERAPY program.

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    APA: Copy

    MADANI, H., ZOLFAGHARI, M.E., SOLTANI, A.A.F., & BEHNAM, BABAK. (2001). APPLICATION OF ALOE GEL FORMULATION IN RADIOTHERAPEUTIC DAMAGE CAUSED BY GAMMA- RAY. HAKIM RESEARCH JOURNAL, 3(4), 274-280. SID. https://sid.ir/paper/29563/en

    Vancouver: Copy

    MADANI H., ZOLFAGHARI M.E., SOLTANI A.A.F., BEHNAM BABAK. APPLICATION OF ALOE GEL FORMULATION IN RADIOTHERAPEUTIC DAMAGE CAUSED BY GAMMA- RAY. HAKIM RESEARCH JOURNAL[Internet]. 2001;3(4):274-280. Available from: https://sid.ir/paper/29563/en

    IEEE: Copy

    H. MADANI, M.E. ZOLFAGHARI, A.A.F. SOLTANI, and BABAK BEHNAM, “APPLICATION OF ALOE GEL FORMULATION IN RADIOTHERAPEUTIC DAMAGE CAUSED BY GAMMA- RAY,” HAKIM RESEARCH JOURNAL, vol. 3, no. 4, pp. 274–280, 2001, [Online]. Available: https://sid.ir/paper/29563/en

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    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
    مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources
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