مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HIGH PLASMA HOMOCYSTEINE AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME

Pages

  223-228

Abstract

 Background: Polycystic ovarian syndrome (PCOS) is a common disease among women in fertility ages and cause severe INSULIN RESISTANCE. Hyperhomocysteinaemia is said to be among the features of PCOS that could influence its outcome.Objective: This study aimed to investigate whether hyperhomocysteinaemia exists in PCOS and if it is related to INSULIN RESISTANCE in the affected patients.Materials and Methods: This prospective study was carried out in a university based fertility clinic. Sixty four PCOS patients and 50 normo ovulatory controls were reviewed for fasting glucose, insulin, HOMOCYSTEINE, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) plasma levels in the blood sample of the 3rd day of their menstrual cycle. INSULIN RESISTANCE was determined with the fasting glucose (mmol/L) to insulin (mIU/L) ratio and HOMA-IR (Homeostasis model assessment-Insulin resistance). Independent-samples T-test and linear regression test were utilized to analyze the obtained data.Results: HOMOCYSTEINE levels compared between PCOS patients and control group showed a significant difference. PCOS group was divided into insulin resistant (IR) (LogHOMA-IR³0.57) and non insulin resistant (NIR) patients. The IR group had significantly higher HOMOCYSTEINE (p-value=0.02), fasting insulin and glucose levels (p-value<0.001) rather than NIR group.Conclusion: PCOS patients have a leaning toward hyperhomocysteinaemia and INSULIN RESISTANCE. Insulin resistant patients are found to have higher HOMOCYSTEINE level.

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    APA: Copy

    HEMATI, TAYEBE, MOGHADAMI TABRIZI, NASRIN, DAVARI TANHA, FATEMEH, SALMANIAN, BAHRAM, & JAVADIAN, POUYA. (2011). HIGH PLASMA HOMOCYSTEINE AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 9(3), 223-228. SID. https://sid.ir/paper/295840/en

    Vancouver: Copy

    HEMATI TAYEBE, MOGHADAMI TABRIZI NASRIN, DAVARI TANHA FATEMEH, SALMANIAN BAHRAM, JAVADIAN POUYA. HIGH PLASMA HOMOCYSTEINE AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2011;9(3):223-228. Available from: https://sid.ir/paper/295840/en

    IEEE: Copy

    TAYEBE HEMATI, NASRIN MOGHADAMI TABRIZI, FATEMEH DAVARI TANHA, BAHRAM SALMANIAN, and POUYA JAVADIAN, “HIGH PLASMA HOMOCYSTEINE AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARIAN SYNDROME,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 9, no. 3, pp. 223–228, 2011, [Online]. Available: https://sid.ir/paper/295840/en

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