EVALUATION THE FREQUENCY OF FACTOR V LEIDEN MUTATION IN PREGNANT WOMEN WITH PREECLAMPSIA SYNDROME IN AN IRANIAN POPULATION

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KARIMI SAMIEH; YAVARIAN MAJID; AZINFAR AZADEH; RAJAEI MINOO; AZIZI KOOTENAEE MARYAM

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Journal: International Journal of Reproductive BioMedicine Year:2012 | Volume:10 | Issue:1 Page(s): 59-66

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Title

EVALUATION THE FREQUENCY OF FACTOR V LEIDEN MUTATION IN PREGNANT WOMEN WITH PREECLAMPSIA SYNDROME IN AN IRANIAN POPULATION

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Keywords

PREECLAMPSIA

FACTOR V LEIDEN MUTATION

OBSTETRIC COMPLICATION

IRAN

Abstract

Background: Role of genetic factors in etiology of PREECLAMPSIA is not confirmed yet.Objective: Gene defect frequency varies in different geographic areas as well as ethnic groups. In this study, the role of FACTOR V LEIDEN MUTATION in the pathogenesis of PREECLAMPSIA syndrome among the pregnant population of northern shore of Persian Gulf in IRAN, were considered.Materials and Methods: Between Jan.2008 and Dec.2009, in a nested case control study, pregnant women with PREECLAMPSIA (N=198) as cases and healthy (N=201) as controls were enrolled in the study. DNA were extracted from 10 CC peripheral blood and analyzed for presence of FACTOR V LEIDEN MUTATION in these subjects. The maternal and neonatal outcomes of pregnancy according to the distribution of factor V Leiden were also compared among cases.Results: In total, 17 (8.6%) of cases and 2 (1%) of controls showed the FACTOR V LEIDEN MUTATION.The incidence of factor V Leiden was typically higher in preeclamptic women than control group (OR: 9.34 %95 CI: 2.12-41.01). There was no difference in incidence rate of preterm delivery<37 weeks (OR: 1.23 %95 CI: 0.38-4.02), very early preterm delivery<32 weeks (OR: 1.00 %95 CI: 0.12-8.46), intra uterine fetal growth restriction (IUGR) (OR: 1.32 %95 CI: 0.15-11.30 ), and the rate of cesarean section (OR: 0.88 %95 CI: 0.29-2.62) among cases based on the prevalence of FACTOR V LEIDEN MUTATION.Conclusion: The pregnant women with FACTOR V LEIDEN MUTATION are prone for PREECLAMPSIA syndrome during pregnancy, but this risk factor was not correlated to pregnancy complications in the studied women.

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APA: Copy

KARIMI, SAMIEH, YAVARIAN, MAJID, AZINFAR, AZADEH, RAJAEI, MINOO, & AZIZI KOOTENAEE, MARYAM. (2012). EVALUATION THE FREQUENCY OF FACTOR V LEIDEN MUTATION IN PREGNANT WOMEN WITH PREECLAMPSIA SYNDROME IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(1), 59-66. SID. https://sid.ir/paper/295853/en

Vancouver: Copy

KARIMI SAMIEH, YAVARIAN MAJID, AZINFAR AZADEH, RAJAEI MINOO, AZIZI KOOTENAEE MARYAM. EVALUATION THE FREQUENCY OF FACTOR V LEIDEN MUTATION IN PREGNANT WOMEN WITH PREECLAMPSIA SYNDROME IN AN IRANIAN POPULATION. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(1):59-66. Available from: https://sid.ir/paper/295853/en

IEEE: Copy

SAMIEH KARIMI, MAJID YAVARIAN, AZADEH AZINFAR, MINOO RAJAEI, and MARYAM AZIZI KOOTENAEE, “EVALUATION THE FREQUENCY OF FACTOR V LEIDEN MUTATION IN PREGNANT WOMEN WITH PREECLAMPSIA SYNDROME IN AN IRANIAN POPULATION,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 1, pp. 59–66, 2012, [Online]. Available: https://sid.ir/paper/295853/en

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