ETIOLOGY OF PRECOCIOUS PUBERTY, 10 YEARS STUDY IN ENDOCRINE RESERCH CENTRE (FIROUZGAR), TEHRAN

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ROHANI FARZANEH; SALEHPUR SHADAB; SAFARI FATEMEH

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Journal: International Journal of Reproductive BioMedicine Year:2012 | Volume:10 | Issue:1 Page(s): 1-6

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Title

ETIOLOGY OF PRECOCIOUS PUBERTY, 10 YEARS STUDY IN ENDOCRINE RESERCH CENTRE (FIROUZGAR), TEHRAN

Author(s)

ROHANI FARZANEH | SALEHPUR SHADAB | SAFARI FATEMEH | Issue Writer Certificate

Keywords

CENTRAL PRECOCIOUS PUBERTY

PERIPHERAL PRECOCIOUS PUBERTY

PREMATURE THELARCHE

CONGENITAL ADRENAL HYPERPLASIA

Abstract

Background: Precocious puberty, as early physical development and low final height might lead to psychosocial problems.Objective: To evaluate etiology and clinical feature of precocious puberty in a cohort of Iranian children.Materials and Methods: In this case-series study, 44 girls and 8 boys with precocious puberty referred to Endocrine Reserch Centre (Firouzgar), Institute of Endocrinology and Metabolism (Hemmat Campus), were examined in a 10 years period of time.Results: Mean age of girls and boys was 7.43±1.4 years and 5.8±2.1 years respectively. Most of the patients fell within the age category of 7-7.9 years old (40.9% for girls and 50% for boys). Patients, concerning etiology of precocious puberty were classified in three categories: 42.6% of patients had CENTRAL PRECOCIOUS PUBERTY (CPP), including idiopathic CPP (87.5%) and neurogenic CPP (12.5%).23.3% of patients had PERIPHERAL PRECOCIOUS PUBERTY (PPP), including CONGENITAL ADRENAL HYPERPLASIA (CAH) (42.8%), ovarian cysts (28.4%), McCune-Albright syndrome (14.2%) and adrenal carcinoma (14.2%).34.1% of girls and 25% of boys had normal variant puberty including PREMATURE THELARCHE (57%), premature adrenarche (38%) as well as premature menarche (4.7%l).Conclusion: The most common etiology of precocious puberty in girls was idiopathic CENTRAL PRECOCIOUS PUBERTY and PREMATURE THELARCHE, while in boys they were neurogenic CENTRAL PRECOCIOUS PUBERTY and CAH. Therefore precocious puberty in girls is usually benign. In boys, CNS anomalies should first be considered in the differential diagnosis of CPP. Therefore brain Magnetic Resonance Imaging (MRI) is mandatory in all cases.

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APA: Copy

ROHANI, FARZANEH, SALEHPUR, SHADAB, & SAFARI, FATEMEH. (2012). ETIOLOGY OF PRECOCIOUS PUBERTY, 10 YEARS STUDY IN ENDOCRINE RESERCH CENTRE (FIROUZGAR), TEHRAN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(1), 1-6. SID. https://sid.ir/paper/295859/en

Vancouver: Copy

ROHANI FARZANEH, SALEHPUR SHADAB, SAFARI FATEMEH. ETIOLOGY OF PRECOCIOUS PUBERTY, 10 YEARS STUDY IN ENDOCRINE RESERCH CENTRE (FIROUZGAR), TEHRAN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(1):1-6. Available from: https://sid.ir/paper/295859/en

IEEE: Copy

FARZANEH ROHANI, SHADAB SALEHPUR, and FATEMEH SAFARI, “ETIOLOGY OF PRECOCIOUS PUBERTY, 10 YEARS STUDY IN ENDOCRINE RESERCH CENTRE (FIROUZGAR), TEHRAN,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 1, pp. 1–6, 2012, [Online]. Available: https://sid.ir/paper/295859/en

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