DOES INHIBIN-B HELP US TO CONFIDENTLY REFUSE DIAGNOSTIC TESTICULAR BIOPSY IN AZOOSPERMIA?

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MORADI MAHMOUDREZA; ALEMI MOHSEN; MORADI ASAAD; IIZADI BABAK; PARHODAH FARAJOLLAH; TORKAMAN ASADI FATEMEH

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Journal: International Journal of Reproductive BioMedicine Year:2012 | Volume:10 | Issue:3 Page(s): 243-248

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Title

DOES INHIBIN-B HELP US TO CONFIDENTLY REFUSE DIAGNOSTIC TESTICULAR BIOPSY IN AZOOSPERMIA?

Author(s)

Keywords

INFERTILITY

HISTOLOGY

SPERM CELL

GERM CELL

DIAGNOSIS

AZOOSPERMIA

Abstract

Background: In the recent years, the use of laboratory blood factors such as FSH and inhibin-B for the assessment of spermatogenesis in different studies has increased; of course, the conflicting results have also been achieved.Objective: To investigate if the measurement of inhibin-B can help surgeon to reduce unnecessary diagnostic testicular biopsies in males with AZOOSPERMIA.Materials and Methods: This cross-sectional study was done during July 2006 to September 2007 on 41 patients with AZOOSPERMIA. FSH and inhibin-B were measured and bilateral open testicular biopsy was performed for all patients.Results: Sperm was seen in 29% of biopsies that in 100% of these samples inhibin-B was more than 100 pg/mL and FSH was less than twice the normal (p=0.001). Inhibin-B had significant correlation inversely with testicular fibrosis and Sertoli cell only syndrome (p=0.043 and p=0.011, respectively) and directly with incomplete spermatocytic maturation arrest and obstructive AZOOSPERMIA (p=0.027 and p=0.013, respectively). FSH was only correlated with obstructive AZOOSPERMIA (p=0.001).Conclusion: We suggest that if FSH is less than twice the normal, inhibin-B should be measured and if its level is less than 100 pg/mL, we can cancel about the half of unnecessary diagnostic testicular biopsies.

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APA: Copy

MORADI, MAHMOUDREZA, ALEMI, MOHSEN, MORADI, ASAAD, IIZADI, BABAK, PARHODAH, FARAJOLLAH, & TORKAMAN ASADI, FATEMEH. (2012). DOES INHIBIN-B HELP US TO CONFIDENTLY REFUSE DIAGNOSTIC TESTICULAR BIOPSY IN AZOOSPERMIA?. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(3), 243-248. SID. https://sid.ir/paper/295888/en

Vancouver: Copy

MORADI MAHMOUDREZA, ALEMI MOHSEN, MORADI ASAAD, IIZADI BABAK, PARHODAH FARAJOLLAH, TORKAMAN ASADI FATEMEH. DOES INHIBIN-B HELP US TO CONFIDENTLY REFUSE DIAGNOSTIC TESTICULAR BIOPSY IN AZOOSPERMIA?. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(3):243-248. Available from: https://sid.ir/paper/295888/en

IEEE: Copy

MAHMOUDREZA MORADI, MOHSEN ALEMI, ASAAD MORADI, BABAK IIZADI, FARAJOLLAH PARHODAH, and FATEMEH TORKAMAN ASADI, “DOES INHIBIN-B HELP US TO CONFIDENTLY REFUSE DIAGNOSTIC TESTICULAR BIOPSY IN AZOOSPERMIA?,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 3, pp. 243–248, 2012, [Online]. Available: https://sid.ir/paper/295888/en

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