OUTCOME OF CRYOPRESERVED-THAWED EMBRYO TRANSFER IN THE GNRH AGONIST VERSUS ANTAGONIST PROTOCOL

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EFTEKHAR MARYAM; DEHGHANI FIROUZABADI RAZIEH; KARIMI HESAMODDIN; RAHMANI ELHAM

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Journal Paper

Paper Information

Journal: International Journal of Reproductive BioMedicine Year:2012 | Volume:10 | Issue:4 Page(s): 297-302

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Title

OUTCOME OF CRYOPRESERVED-THAWED EMBRYO TRANSFER IN THE GNRH AGONIST VERSUS ANTAGONIST PROTOCOL

Author(s)

EFTEKHAR MARYAM | DEHGHANI FIROUZABADI RAZIEH | KARIMI HESAMODDIN | RAHMANI ELHAM | Issue Writer Certificate

Keywords

GNRH AGONIST

GNRH ANTAGONIST

CRYOPRESERVED

EMBRYO TRANSFER

PREGNANCY OUTCOME

Abstract

Background: GNRH AGONIST and antagonist were developed to control the premature release of LH surge. There is some difference between two protocols.Objective: We compared the outcome of frozen-thawed EMBRYO TRANSFER in infertile women who used GNRH AGONIST or antagonist protocol for previous COH cycle and evaluation of any adverse effect of GNRH ANTAGONIST on oocyte and embryo.Materials and Methods: The study group included all infertile women who referred to Yazd Research and Clinical Center for Infertility. Overall 20-35 years old women who were candidate for frozen-thawed EMBRYO TRANSFER with regard to inclusion and exclusion criteria were participated in the study. The patients based on previous control ovarian stimulation (COH) protocol divided in to two groups: GNRH AGONIST long protocol (n=165) and GNRH ANTAGONIST multiple dose protocol (n=165). Frozen-thawed embryos were transferred after endometrial preparation in both groups. Main outcome measures were: implantation, chemical and clinical pregnancy rate.Results: The implantation and clinical pregnancy rate following CRYOPRESERVED EMBRYO TRANSFER in GNRH AGONIST group and antagonist group were 16.3% vs. 15.7% (p=0.806) and 38.1% (63.165) vs.36.9% (61.165) (p=0.915) and chemical pregnancy rate was 44.8% (74.165) vs.43.6% (72.165) (p=0.915) respectively.Conclusion: There was no statistically difference between two groups in terms of implantation and pregnancy rate. Although pregnancy rate in fresh EMBRYO TRANSFER in antagonist cycles was lower than agonist groups, Therefore decrease in these parameters might be due to detrimental effect of GNRH ANTAGONIST on the endometrium, not embryo or oocyte.

Cites

BISHOP SCORE PREDICTIVE VALUE IN SUCCESS OF INDUCED LABOR PROCESS AMONG FULL TERM PREGNANT WOMEN REFERRED TO PERSIAN GULF MARTYRS’ HOSPITAL IN BUSHEHR IN 2013

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APA: Copy

EFTEKHAR, MARYAM, DEHGHANI FIROUZABADI, RAZIEH, KARIMI, HESAMODDIN, & RAHMANI, ELHAM. (2012). OUTCOME OF CRYOPRESERVED-THAWED EMBRYO TRANSFER IN THE GNRH AGONIST VERSUS ANTAGONIST PROTOCOL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(4), 297-302. SID. https://sid.ir/paper/295907/en

Vancouver: Copy

EFTEKHAR MARYAM, DEHGHANI FIROUZABADI RAZIEH, KARIMI HESAMODDIN, RAHMANI ELHAM. OUTCOME OF CRYOPRESERVED-THAWED EMBRYO TRANSFER IN THE GNRH AGONIST VERSUS ANTAGONIST PROTOCOL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(4):297-302. Available from: https://sid.ir/paper/295907/en

IEEE: Copy

MARYAM EFTEKHAR, RAZIEH DEHGHANI FIROUZABADI, HESAMODDIN KARIMI, and ELHAM RAHMANI, “OUTCOME OF CRYOPRESERVED-THAWED EMBRYO TRANSFER IN THE GNRH AGONIST VERSUS ANTAGONIST PROTOCOL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 4, pp. 297–302, 2012, [Online]. Available: https://sid.ir/paper/295907/en

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