COMPARISON OF RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE (RHFSH), HUMAN CHORIONIC GONADOTROPIN (HCG) AND HUMAN MENOPAUSAL GONADOTROPIN (HMG) ON SEMEN PARAMETERS AFTER VARICOCELECTOMY: A RANDOMIZED CLINICAL TRIAL

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AMIRZARGAR MOHAMMAD ALI; YAVANGI MAHNAZ; BASIRI ABBAS; HOSSEINI MOGHADDAM SAYYED MAHDI; BABBOLHAVAEJI HOOSHANG; AMIRZARGAR NASIBEH; AMIRZARGAR HOSSEIN; MOADABSHOAR LEILA

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Journal: International Journal of Reproductive BioMedicine Year:2012 | Volume:10 | Issue:5 Page(s): 441-452

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Title

COMPARISON OF RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE (RHFSH), HUMAN CHORIONIC GONADOTROPIN (HCG) AND HUMAN MENOPAUSAL GONADOTROPIN (HMG) ON SEMEN PARAMETERS AFTER VARICOCELECTOMY: A RANDOMIZED CLINICAL TRIAL

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Keywords

MALE INFERTILITY

SEMEN ANALYSES

VARICOCELE

VARICOCELECTOMY

HCG

HMG

RHFSH

Abstract

Background: The most frequent physical finding in infertile men is VARICOCELE, in which one of the mechanisms that can affect seminal parameters is oxidative stress.Objective: Our study aimed, for the first time, to compare the efficacy of recombinant human follicle-stimulating hormone (rhFSH), human chorionic gonadotropin (HCG) and human menopausal gonadotropin (HMG) on sperm parameters and fertility after VARICOCELEctomy.Materials and Methods: 113 infertile men with VARICOCELE were divided into four groups. Group A received HCG 5000 IU weekly, group B received HMG 75 IU three times a week, group C received RHFSH 75 IU three times a week and group D received no medical treatment after VARICOCELEctomy.Results: After three months, in group A sperm morphology improved (p=0.007), causing a 32% pregnancy rate. In group B, sperm motility (p=0.023) and morphology (p=0.014) improved, causing a 57% pregnancy rate. In group C, all of the investigated semen parameters increased (p<0.05), causing a 62.5% pregnancy rate. Only RHFSH improved sperm concentrations to>20×106 mL (p=0.027). In group D, sperm morphology increased (p=0.038), but other parameters remained unchanged and no pregnancies occurred.Conclusion: It can be concluded that drugs can reduce induction time for spermatogenesis and fertility in comparison with VARICOCELEctomy alone. For these purposes, RHFSH is more effective than other drugs.

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APA: Copy

AMIRZARGAR, MOHAMMAD ALI, YAVANGI, MAHNAZ, BASIRI, ABBAS, HOSSEINI MOGHADDAM, SAYYED MAHDI, BABBOLHAVAEJI, HOOSHANG, AMIRZARGAR, NASIBEH, AMIRZARGAR, HOSSEIN, & MOADABSHOAR, LEILA. (2012). COMPARISON OF RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE (RHFSH), HUMAN CHORIONIC GONADOTROPIN (HCG) AND HUMAN MENOPAUSAL GONADOTROPIN (HMG) ON SEMEN PARAMETERS AFTER VARICOCELECTOMY: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 10(5), 441-452. SID. https://sid.ir/paper/295911/en

Vancouver: Copy

AMIRZARGAR MOHAMMAD ALI, YAVANGI MAHNAZ, BASIRI ABBAS, HOSSEINI MOGHADDAM SAYYED MAHDI, BABBOLHAVAEJI HOOSHANG, AMIRZARGAR NASIBEH, AMIRZARGAR HOSSEIN, MOADABSHOAR LEILA. COMPARISON OF RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE (RHFSH), HUMAN CHORIONIC GONADOTROPIN (HCG) AND HUMAN MENOPAUSAL GONADOTROPIN (HMG) ON SEMEN PARAMETERS AFTER VARICOCELECTOMY: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2012;10(5):441-452. Available from: https://sid.ir/paper/295911/en

IEEE: Copy

MOHAMMAD ALI AMIRZARGAR, MAHNAZ YAVANGI, ABBAS BASIRI, SAYYED MAHDI HOSSEINI MOGHADDAM, HOOSHANG BABBOLHAVAEJI, NASIBEH AMIRZARGAR, HOSSEIN AMIRZARGAR, and LEILA MOADABSHOAR, “COMPARISON OF RECOMBINANT HUMAN FOLLICLE STIMULATING HORMONE (RHFSH), HUMAN CHORIONIC GONADOTROPIN (HCG) AND HUMAN MENOPAUSAL GONADOTROPIN (HMG) ON SEMEN PARAMETERS AFTER VARICOCELECTOMY: A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 10, no. 5, pp. 441–452, 2012, [Online]. Available: https://sid.ir/paper/295911/en

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