RECURRENT IVF FAILURE AND HEREDITARY THROMBOPHILIA

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SAFDARIAN LEILA; NAJMI ZAHRA; ALEYASIN ASHRAF; AGHAHOSSEINI MARZIEH; RASHIDI MANDANA; ASADOLLAH SARA

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2014 | Volume:12 | Issue:7 Page(s): 467-470

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Title

RECURRENT IVF FAILURE AND HEREDITARY THROMBOPHILIA

Author(s)

Keywords

RECURRENT IMPLANTATION FAILURE

IN VITRO FERTILIZATION

HEREDITARY THROMBOPHILIA

Abstract

Background: The largest percentage of failed invitro fertilization (IVF) cycles, are due to lack of implantation. As HEREDITARY THROMBOPHILIA can cause in placentation failure, it may have a role in recurrent IVF failure.Objective: Aim of this case-control study was to determine whether HEREDITARY THROMBOPHILIA is more prevalent in women with recurrent IVF failures.Materials and Methods: Case group comprised 96 infertile women, with a history of recurrent IVF failure. Control group was comprised of 95 healthy women with proven fertility who had conceived spontaneously. All participants were assessed for the presence of inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin mutation, homocystein level, protein S and C deficiency, antithrombin III (AT-III) deficiency and plasminogen activator inhibitor-1 (PAI-1) mutation. Presence of thrombophilia was compared between groups.Results: Having at least one thrombophilia known as a risk factor for recurrent IVF failure (95% CI=1.74-5.70, OR=3.15, p=0.00). Mutation of factor V Leiden (95% CI=1.26-10.27, OR=3.06, P=0.01) and homozygote form of MTHFR mutation (95% CI=1.55-97.86, OR=12.33, p=0.05) were also risk factors for recurrent IVF failure. However, we could not find significant difference in other inherited thrombophilia’s.

Cites

Detection of 4977-bp deletion of mitochondrial DNA in in vitro fertilization failure women: A case-control study

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APA: Copy

SAFDARIAN, LEILA, NAJMI, ZAHRA, ALEYASIN, ASHRAF, AGHAHOSSEINI, MARZIEH, RASHIDI, MANDANA, & ASADOLLAH, SARA. (2014). RECURRENT IVF FAILURE AND HEREDITARY THROMBOPHILIA. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(7), 467-470. SID. https://sid.ir/paper/295989/en

Vancouver: Copy

SAFDARIAN LEILA, NAJMI ZAHRA, ALEYASIN ASHRAF, AGHAHOSSEINI MARZIEH, RASHIDI MANDANA, ASADOLLAH SARA. RECURRENT IVF FAILURE AND HEREDITARY THROMBOPHILIA. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2014;12(7):467-470. Available from: https://sid.ir/paper/295989/en

IEEE: Copy

LEILA SAFDARIAN, ZAHRA NAJMI, ASHRAF ALEYASIN, MARZIEH AGHAHOSSEINI, MANDANA RASHIDI, and SARA ASADOLLAH, “RECURRENT IVF FAILURE AND HEREDITARY THROMBOPHILIA,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 12, no. 7, pp. 467–470, 2014, [Online]. Available: https://sid.ir/paper/295989/en

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