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Cites:

1

Information Journal Paper

Title

PREVALENCE AND PATTERNS OF Y CHROMOSOME MICRODELETION IN INFERTILE MEN WITH AZOOSPERMIA AND OLIGZOOSPERMIA IN NORTHEAST CHINA

Pages

  383-388

Abstract

 Background: In some cases infertile men showed small deletions of specific genes in the Y chromosome. It had been confirmed, these deleted genes are greatly associated with spermatogenic failure. However, the frequency and the patterns of such microdeletions among infertile men are not clearly clarified.Objective: We sought to determine the frequency and the patterns of Y CHROMOSOME MICRODELETIONS in azoospermic and oligozoospermic infertile men in Northeast China, and try to optimize the selection of sequence tagged sites (STSs) of AZF microdeletions in multiplex polymerase chain reaction (PCR).Materials and Methods: 720 azoospermic and 330 oligozoospermic infertile men, from Northeast China were included in this retrospective study during May 2008 to November 2012. Semen analysis was performed according to the World Health Organization guidelines. Y CHROMOSOME MICRODELETIONS were detected by polymerase chain reaction assays. G-banding method was used for chromosome Karyotype analysis. Chi-square tests were used to compare patterns of Y CHROMOSOME MICRODELETIONS in azoospermic and oligozoospermic patients.Results: Of 1050 infertile men, 12.95% cases had shown Y CHROMOSOME MICRODELETIONS, and 19.43% of cases showed abnormal chromosomal karyotype. Deletions in AZFc region was the most frequent 75.00%, followed by deletions in AZFb region 13.33%, AZFbc region 09.62%, and AZFa region 2.22%. All oligozoospermic patients showed presence of sY84, sY86, sY127, and sY134. Deletion of sY127 (p=0.0101) and sY157 (p=0.0043) showed significant difference between azoospermic group and oligozoospermic group.Conclusion: Deletions of sY127 may relate to AZOOSPERMIA while sY84, sY86, sY127 can be ignored in AZF screening for oligozoospermic patients.

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    APA: Copy

    ELFATEH, FADLALLA, RULIN, DAI, XIN, YUN, LINLIN, LI, HAIBO, ZHU, & LIU, RUI ZHI. (2014). PREVALENCE AND PATTERNS OF Y CHROMOSOME MICRODELETION IN INFERTILE MEN WITH AZOOSPERMIA AND OLIGZOOSPERMIA IN NORTHEAST CHINA. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(6), 383-388. SID. https://sid.ir/paper/296004/en

    Vancouver: Copy

    ELFATEH FADLALLA, RULIN DAI, XIN YUN, LINLIN LI, HAIBO ZHU, LIU RUI ZHI. PREVALENCE AND PATTERNS OF Y CHROMOSOME MICRODELETION IN INFERTILE MEN WITH AZOOSPERMIA AND OLIGZOOSPERMIA IN NORTHEAST CHINA. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2014;12(6):383-388. Available from: https://sid.ir/paper/296004/en

    IEEE: Copy

    FADLALLA ELFATEH, DAI RULIN, YUN XIN, LI LINLIN, ZHU HAIBO, and RUI ZHI LIU, “PREVALENCE AND PATTERNS OF Y CHROMOSOME MICRODELETION IN INFERTILE MEN WITH AZOOSPERMIA AND OLIGZOOSPERMIA IN NORTHEAST CHINA,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 12, no. 6, pp. 383–388, 2014, [Online]. Available: https://sid.ir/paper/296004/en

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