INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL

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ZAREI AFSOON; PARSANEZHAD MOHAMMAD EBRAHIM; YOUNESI MASOUMEH; ALBORZI SAEED; ZOLGHADRI JALEH; SAMSAMI ALAMTAJ; AMOOEE SEDIGHEH; ARAMESH SHAHINTAJ

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Journal: International Journal of Reproductive BioMedicine Year:2014 | Volume:12 | Issue:1 Page(s): 1-6

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Title

INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL

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Keywords

RECOMBINANT HUMAN CHORIONIC GONADOTROPIN (RHCG)

INTRACYTOPLASMIC SPERM INJECTION (ICSI)

IN VITRO FERTILIZATION (IVF)

IMPLANTATION RATE

PREGNANCY RATE

Abstract

Background: The direct effect of hCG on the human endometrium was studied several times.Objective: The objectives of this study were to evaluate the effectiveness of intrauterine injection of recombinant human chorionic gonadotropin (rhCG) before embryo transfer (ET).Materials and Methods: In this randomized placebo-controlled clinical trial, a total number of 182 infertile patients undergoing their first in vitro fertilization/ intracytoplasmic sperm injection (IVF-ICSI) cycles were randomly assigned to receive 250mg intrauterine rhCG (n=84) or placebo (n=98) before ET. The implantation and PREGNANCY RATEs were compared between groups.Results: Patients who received intrauterine rhCG before ET had significantly higher implantation (36.9% vs. 22.4%; p=0.035), clinical PREGNANCY RATEs (34.5% vs. 20.4%; p=0.044) and ongoing PREGNANCY RATE (32.1% vs. 18.4%; p=0.032) when compared to those who received placebo. The abortion (2.4% vs. 2.0%; p=0.929) and ectopic PREGNANCY RATEs (1.2% vs. 1.0%; p=0.976) were comparable between groups of rhCG and placebo, respectively.Conclusion: Intrauterine injection of 250mg of rhCG before ET significantly improves the implantation and PREGNANCY RATEs in IVF/ICSI cycles.

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APA: Copy

ZAREI, AFSOON, PARSANEZHAD, MOHAMMAD EBRAHIM, YOUNESI, MASOUMEH, ALBORZI, SAEED, ZOLGHADRI, JALEH, SAMSAMI, ALAMTAJ, AMOOEE, SEDIGHEH, & ARAMESH, SHAHINTAJ. (2014). INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(1), 1-6. SID. https://sid.ir/paper/296046/en

Vancouver: Copy

ZAREI AFSOON, PARSANEZHAD MOHAMMAD EBRAHIM, YOUNESI MASOUMEH, ALBORZI SAEED, ZOLGHADRI JALEH, SAMSAMI ALAMTAJ, AMOOEE SEDIGHEH, ARAMESH SHAHINTAJ. INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2014;12(1):1-6. Available from: https://sid.ir/paper/296046/en

IEEE: Copy

AFSOON ZAREI, MOHAMMAD EBRAHIM PARSANEZHAD, MASOUMEH YOUNESI, SAEED ALBORZI, JALEH ZOLGHADRI, ALAMTAJ SAMSAMI, SEDIGHEH AMOOEE, and SHAHINTAJ ARAMESH, “INTRAUTERINE ADMINISTRATION OF RECOMBINANT HUMAN CHORIONIC GONADOTROPIN BEFORE EMBRYO TRANSFER ON OUTCOME OF IN VITRO FERTILIZATION/ INTRACYTOPLASMIC SPERM INJECTION: A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 12, no. 1, pp. 1–6, 2014, [Online]. Available: https://sid.ir/paper/296046/en

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