EFFECTIVENESS OF ASPIRIN COMPARE WITH HEPARIN PLUS ASPIRIN IN RECURRENT PREGNANCY LOSS TREATMENT: A QUASI EXPERIMENTAL STUDY

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GHASEMI NASRIN; JAHANINEJAD TAHEREH; MOSTAFAVI MAHDIA SADAT; AFLATOONIAN ABBAS

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Journal: International Journal of Reproductive BioMedicine Year:2014 | Volume:12 | Issue:1 Page(s): 73-76

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Title

EFFECTIVENESS OF ASPIRIN COMPARE WITH HEPARIN PLUS ASPIRIN IN RECURRENT PREGNANCY LOSS TREATMENT: A QUASI EXPERIMENTAL STUDY

Author(s)

GHASEMI NASRIN | JAHANINEJAD TAHEREH | MOSTAFAVI MAHDIA SADAT | AFLATOONIAN ABBAS | Issue Writer Certificate

Keywords

THROMBOPHILIA

RECURRENT MISCARRIAGE

ANTICOAGULANT

LIVE BIRTH

ASPIRIN

HEPARIN

Abstract

Background: Using ASPIRIN, HEPARIN, or both in women with unexplained RECURRENT MISCARRIAGE could be useful, because this problem might be initiated by thrombosis in decidual vessels.Objective: To investigate the association between THROMBOPHILIA and unexplained RECURRENT MISCARRIAGE and to evaluate the efficacy of ANTICOAGULANT treatment.Materials and Methods: In this quasi experimental, we enrolled 520 women, who had a history of RECURRENT MISCARRIAGE. Two hundred fifty two women with unexplained RECURRENT MISCARRIAGE were assigned to receive ASPIRIN (80 mg daily) for two month before pregnancy and after confirmation of a viable pregnancy until 36 weeks of gestation or receive ASPIRIN, as the same, plus HEPARIN (5000 unit twice a day) subcutaneously after confirmation of viable pregnancy until 4 weeks after delivery. Type of medication was chosen for each woman according to number of abortion and age.Results: Live-birth rates did not different significantly among the two study groups. The proportions of women who gave birth to a live normal infant were 74.5% in the group receiving ASPIRIN plus HEPARIN (combination-therapy group) and 79.8% in the ASPIRIN group.Conclusion: Live-birth rates did not different significantly among the two study groups. So, using ASPIRIN or ASPIRIN plus HEPARIN did not change pregnancy rate in these patients. Using ASPIRIN is easier than injecting HEPARIN which should be chosen case by case.

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APA: Copy

GHASEMI, NASRIN, JAHANINEJAD, TAHEREH, MOSTAFAVI, MAHDIA SADAT, & AFLATOONIAN, ABBAS. (2014). EFFECTIVENESS OF ASPIRIN COMPARE WITH HEPARIN PLUS ASPIRIN IN RECURRENT PREGNANCY LOSS TREATMENT: A QUASI EXPERIMENTAL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 12(1), 73-76. SID. https://sid.ir/paper/296050/en

Vancouver: Copy

GHASEMI NASRIN, JAHANINEJAD TAHEREH, MOSTAFAVI MAHDIA SADAT, AFLATOONIAN ABBAS. EFFECTIVENESS OF ASPIRIN COMPARE WITH HEPARIN PLUS ASPIRIN IN RECURRENT PREGNANCY LOSS TREATMENT: A QUASI EXPERIMENTAL STUDY. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2014;12(1):73-76. Available from: https://sid.ir/paper/296050/en

IEEE: Copy

NASRIN GHASEMI, TAHEREH JAHANINEJAD, MAHDIA SADAT MOSTAFAVI, and ABBAS AFLATOONIAN, “EFFECTIVENESS OF ASPIRIN COMPARE WITH HEPARIN PLUS ASPIRIN IN RECURRENT PREGNANCY LOSS TREATMENT: A QUASI EXPERIMENTAL STUDY,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 12, no. 1, pp. 73–76, 2014, [Online]. Available: https://sid.ir/paper/296050/en

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