Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

407
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

178
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

2

Information Journal Paper

Title

THE FREQUENCY OF YQ MICRODELETION IN AZOOSPERMIC AND OLIGOSPERMIC IRANIAN INFERTILE MEN

Pages

  453-458

Abstract

 Background: About 15% of couples have infertility problems which 40% of them are related to the male factors. Genetic factors are candidate for about 10% of MALE INFERTILITY conditions. Among these, AZFa, AZFb, AZFc and AZFd regions on the Yq are considered most important for spermatogenesis. Microdeletions of these regions are thought to be involved in some cases of azoospermic or oligospermic infertile men.Objective: We studied the prevalence of AZF MICRODELETIONs among Iranian infertile men with non-obstructive azoospermia and oligospermia. Materials and Methods: A total of 50 Iranian azoospermic and oligospermic infertile men were selected for case group and 50 men with normal spermogram as control group. The molecular study of Y chromosome microdeletions was done by MULTIPLEX POLYMERASE CHAIN REACTION (M-PCR) method by using of 13 sequence tagged site (STS) markers from AZF region.Results: Four (8%) patients showed Y chromosome microdeletions among case group, deletion in AZFc region was the most frequent (80%) followed by AZFb (20%), in AZFa and AZFd region we did not detect any deletions. No deletion was detected in control group; the ratio of Y chromosome microdeletion in azoospermic men was higher than this ratio in oligospermic men [19% (3.16) among azoospermic men and 3% (1.34) among oligospermics]. Serum FSH level in men with microdeletions was higher than this level in men with no deletions (p=0.034).Conclusion: Because of relatively high prevalence of microdeletions on the long arm of Y chromosome among Iranian azoospermic and oligospermic patients, screening of this microdeletion may be advised to infertile men particularly azoospermic and oligospermic men before using assisted reproductive treatments.

Cites

References

  • No record.

    • Cite

    APA: Copy

    ZAIMY, MOHAMMAD ALI, KALANTAR, SEYED MEHDI, SHEIKHHA, MOHAMMAD HASAN, JAHANINEJAD, TAHERE, PASHAIEFAR, HOSSEIN, GHASEMZADE, JALAL, & ZAHRAEI, MAHNAZ. (2013). THE FREQUENCY OF YQ MICRODELETION IN AZOOSPERMIC AND OLIGOSPERMIC IRANIAN INFERTILE MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(6), 453-458. SID. https://sid.ir/paper/296073/en

    Vancouver: Copy

    ZAIMY MOHAMMAD ALI, KALANTAR SEYED MEHDI, SHEIKHHA MOHAMMAD HASAN, JAHANINEJAD TAHERE, PASHAIEFAR HOSSEIN, GHASEMZADE JALAL, ZAHRAEI MAHNAZ. THE FREQUENCY OF YQ MICRODELETION IN AZOOSPERMIC AND OLIGOSPERMIC IRANIAN INFERTILE MEN. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(6):453-458. Available from: https://sid.ir/paper/296073/en

    IEEE: Copy

    MOHAMMAD ALI ZAIMY, SEYED MEHDI KALANTAR, MOHAMMAD HASAN SHEIKHHA, TAHERE JAHANINEJAD, HOSSEIN PASHAIEFAR, JALAL GHASEMZADE, and MAHNAZ ZAHRAEI, “THE FREQUENCY OF YQ MICRODELETION IN AZOOSPERMIC AND OLIGOSPERMIC IRANIAN INFERTILE MEN,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 6, pp. 453–458, 2013, [Online]. Available: https://sid.ir/paper/296073/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top