EFFECT OF OOCYTE ACTIVATION WITH CALCIUM IONOPHORE ON ICSI OUTCOMES IN TERATOSPERMIA: A RANDOMIZED CLINICAL TRIAL

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EFTEKHAR MARYAM; JANATI SIMA; RAHSEPAR MOZHGAN; AFLATOONIAN ABBAS

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:11 Page(s): 875-882

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Title

EFFECT OF OOCYTE ACTIVATION WITH CALCIUM IONOPHORE ON ICSI OUTCOMES IN TERATOSPERMIA: A RANDOMIZED CLINICAL TRIAL

Author(s)

EFTEKHAR MARYAM | JANATI SIMA | RAHSEPAR MOZHGAN | AFLATOONIAN ABBAS | Issue Writer Certificate

Keywords

INTRACYTOPLASMIC SPERM INJECTION

CALCIUM IONOPHORE

OOCYTE ACTIVATION

FERTILIZATION

Abstract

Background: Chemical activation is the most frequently used method for artificial OOCYTE ACTIVATION (AOA), results in high FERTILIZATION rates.Objective: This prospective, randomized, unblinded clinical study aimed to evaluate the efficiency of CALCIUM IONOPHORE on FERTILIZATION and pregnancy rate after INTRACYTOPLASMIC SPERM INJECTION (ICSI) in infertile men suffer from teratoospermia.Materials and Methods: Thirty eight women with teratoospermic partner underwent ICSI with GnRH-antagonist protocol. A total of 313 metaphase II (MII) oocytes were randomly divided after ICSI into two groups: In the oocytes of the control group (n=145), routine ICSI was applied. Oocytes in the AOA group (n=168) immediately after ICSI, were cultured in culture medium supplemented with 5 mΜ calcium/100 mM CALCIUM IONOPHORE (A23187) for 5 minutes and then washed at least three times with MOPS solution. In both groups, the FERTILIZATION was evaluated 16-18 hours after ICSI.Results: The number of embryos obtained and fertilized oocytes were significantly different between two groups (p=0.04). There was no significant difference between the two studied groups regarding the FERTILIZATION and cleavage rate (95.33% vs. 89.56 %; and 84.4% vs. 87.74%; respectively, p=0.06). Implantation rate was higher in AOA group than in control group, but the difference was not significant. (17.64% vs. 7.4%, p=0.14). No significant differences were observed in chemical and clinical pregnancy rate between groups (47.1% vs. 16.7%, p=0.07; and 41.2% vs. 16.7%; p=0.14, respectively).Conclusion: OOCYTE ACTIVATION with CALCIUM IONOPHORE may improve ICSI outcomes in infertile men suffer from teratoospermia. Although, we found no significant difference in the implantation and pregnancy rate between the two groups of patients. Further study with more cases can provide greater value.

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APA: Copy

EFTEKHAR, MARYAM, JANATI, SIMA, RAHSEPAR, MOZHGAN, & AFLATOONIAN, ABBAS. (2013). EFFECT OF OOCYTE ACTIVATION WITH CALCIUM IONOPHORE ON ICSI OUTCOMES IN TERATOSPERMIA: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(11), 875-882. SID. https://sid.ir/paper/296097/en

Vancouver: Copy

EFTEKHAR MARYAM, JANATI SIMA, RAHSEPAR MOZHGAN, AFLATOONIAN ABBAS. EFFECT OF OOCYTE ACTIVATION WITH CALCIUM IONOPHORE ON ICSI OUTCOMES IN TERATOSPERMIA: A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(11):875-882. Available from: https://sid.ir/paper/296097/en

IEEE: Copy

MARYAM EFTEKHAR, SIMA JANATI, MOZHGAN RAHSEPAR, and ABBAS AFLATOONIAN, “EFFECT OF OOCYTE ACTIVATION WITH CALCIUM IONOPHORE ON ICSI OUTCOMES IN TERATOSPERMIA: A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 11, pp. 875–882, 2013, [Online]. Available: https://sid.ir/paper/296097/en

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