COMPARISON OF ORAL DYDROGESTERONE WITH SUPPOSITORY VAGINAL PROGESTERONE FOR LUTEAL-PHASE SUPPORT IN IN VITRO FERTILIZATION (IVF): A RANDOMIZED CLINICAL TRIAL

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SALEHPOUR SAGHAR; TAMIMI MARYAM; SAHARKHIZ NASRIN

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Journal Paper

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Journal: International Journal of Reproductive BioMedicine Year:2013 | Volume:11 | Issue:11 Page(s): 913-918

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Title

COMPARISON OF ORAL DYDROGESTERONE WITH SUPPOSITORY VAGINAL PROGESTERONE FOR LUTEAL-PHASE SUPPORT IN IN VITRO FERTILIZATION (IVF): A RANDOMIZED CLINICAL TRIAL

Author(s)

SALEHPOUR SAGHAR | TAMIMI MARYAM | SAHARKHIZ NASRIN | Issue Writer Certificate

Keywords

IN VITRO FERTILIZATION

LUTEAL-PHASE SUPPORT

DYDROGESTERONE

VAGINAL PROGESTERONE

Abstract

Background: Luteal phase support is mandatory in assisted reproductive technologies (ART) for optimizing outcome, so the luteal phase is supported with either progesterone, addition of estradiol to progesterone, hCG or gonadotropin releasing hormone (GnRH) agonists. Supplementation of luteal phase with progesterone is prescribed for women undergoing routine IVF treatment.Objective: To compare oral dydrogestrone with VAGINAL PROGESTERONE for LUTEAL-PHASE SUPPORT in IVF.Materials and Methods: We performed this prospective, randomized trial in a tertiary infertility care unit in Taleghani Hospital, Tehran, Iran. In total 80 Women with a history of male factor infertility undergoing controlled ovarian stimulation for IVF treatment (fresh cycle) randomly were divided in two groups (group A or oral DYDROGESTERONE group and group B or VAGINAL PROGESTERONE group). The inclusion criteria were the use of GnRH analogue down-regulation and age less than 40 years old with regular menstrual cycles. All women were euthyroid and normoprolactinemic. Group A (n=40) received 10 mg DYDROGESTERONE QID (40mg daily) and group B (n=40) received 400 mg suppository VAGINAL PROGESTERONE (cyclogest) twice per day (800 mg daily).Results: Clinical pregnancy rate in cyclogest group was higher than DYDROGESTERONE group but the difference was not significant (p=0.52), furthermore the miscarriage rate in two group was the same. The difference between two groups regarding antral follicle, embryo number, luteal-phase duration, endometrial thickness, oocyte number and metaphase-II was not significant (p>0.05).Conclusion: The results showed that oral DYDROGESTERONE is as effective as VAGINAL PROGESTERONE for LUTEAL-PHASE SUPPORT in women undergoing IVF.

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APA: Copy

SALEHPOUR, SAGHAR, TAMIMI, MARYAM, & SAHARKHIZ, NASRIN. (2013). COMPARISON OF ORAL DYDROGESTERONE WITH SUPPOSITORY VAGINAL PROGESTERONE FOR LUTEAL-PHASE SUPPORT IN IN VITRO FERTILIZATION (IVF): A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 11(11), 913-918. SID. https://sid.ir/paper/296101/en

Vancouver: Copy

SALEHPOUR SAGHAR, TAMIMI MARYAM, SAHARKHIZ NASRIN. COMPARISON OF ORAL DYDROGESTERONE WITH SUPPOSITORY VAGINAL PROGESTERONE FOR LUTEAL-PHASE SUPPORT IN IN VITRO FERTILIZATION (IVF): A RANDOMIZED CLINICAL TRIAL. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2013;11(11):913-918. Available from: https://sid.ir/paper/296101/en

IEEE: Copy

SAGHAR SALEHPOUR, MARYAM TAMIMI, and NASRIN SAHARKHIZ, “COMPARISON OF ORAL DYDROGESTERONE WITH SUPPOSITORY VAGINAL PROGESTERONE FOR LUTEAL-PHASE SUPPORT IN IN VITRO FERTILIZATION (IVF): A RANDOMIZED CLINICAL TRIAL,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 11, no. 11, pp. 913–918, 2013, [Online]. Available: https://sid.ir/paper/296101/en

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