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Information Journal Paper

Title

SULF 1 GENE POLYMORPHISM, RS6990375 IS IN SIGNIFICANT ASSOCIATION WITH FETUS FAILURE IN IVF TECHNIQUE

Pages

  215-220

Abstract

 Background: Sulfatase 1 (SULF1) function is to remove the 6-O-sulphate group from heparan sulfate. This action changes the binding sites of extracellular growth factors. SULF1 expression has been reported to be changed in angiogenesis. We hypothesized that SINGLE NUCLEOTIDE POLYMORPHISMs (SNPs) of SULF1 would impact clinicopathologic characteristics.Objective: Study of SULF1 GENE polymorphism with fetus failure in in vitro fertilization (IVF) technique.Materials and Methods: We studied one common (minor allele frequency >0.05) regulatory SNP, RS6990375, with POLYMERASE CHAIN REACTION and restriction fragment length polymorphism method, in 53 infertile women with fetus failure in IVF technique and 53 women with at least one healthy child as controls.Results: We found that RS6990375 is significantly associated with an early failure in IVF and frequency of G allele is high in women with fetus failure in IVF technique (p<0.001).Conclusion: These findings suggest that SULF1genetic variations may play a role in IVF technique fetus failure. Further studies with large sample sizes on SULF1 SNPs may be useful in support of this claim.

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    APA: Copy

    TAGHIZADEH, ESKANDAR, KALANTAR, SEYED MEHDI, MAHDIAN, REZA, SHEIKHHA, MOHAMMAD HASAN, FARASHAHI YAZD, EHSAN, GHASEMI ESMAILABAD, SAEED, & SHAHBAZI, ZAHRA. (2015). SULF 1 GENE POLYMORPHISM, RS6990375 IS IN SIGNIFICANT ASSOCIATION WITH FETUS FAILURE IN IVF TECHNIQUE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 13(4), 215-220. SID. https://sid.ir/paper/296203/en

    Vancouver: Copy

    TAGHIZADEH ESKANDAR, KALANTAR SEYED MEHDI, MAHDIAN REZA, SHEIKHHA MOHAMMAD HASAN, FARASHAHI YAZD EHSAN, GHASEMI ESMAILABAD SAEED, SHAHBAZI ZAHRA. SULF 1 GENE POLYMORPHISM, RS6990375 IS IN SIGNIFICANT ASSOCIATION WITH FETUS FAILURE IN IVF TECHNIQUE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2015;13(4):215-220. Available from: https://sid.ir/paper/296203/en

    IEEE: Copy

    ESKANDAR TAGHIZADEH, SEYED MEHDI KALANTAR, REZA MAHDIAN, MOHAMMAD HASAN SHEIKHHA, EHSAN FARASHAHI YAZD, SAEED GHASEMI ESMAILABAD, and ZAHRA SHAHBAZI, “SULF 1 GENE POLYMORPHISM, RS6990375 IS IN SIGNIFICANT ASSOCIATION WITH FETUS FAILURE IN IVF TECHNIQUE,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 13, no. 4, pp. 215–220, 2015, [Online]. Available: https://sid.ir/paper/296203/en

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