EFFECTS OF PORTULACA OLERACEA ETHANOLIC EXTRACT ON REPRODUCTIVE SYSTEM OF AGING FEMALE MICE

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AHANGARPOUR AKRAM; LAMOOCHI ZOHREH; FATHI MOGHADDAM HADI; MANSOURI SEYED MOHAMMAD TAGHI

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Journal: International Journal of Reproductive BioMedicine Year:2016 | Volume:14 | Issue:3 Page(s): 205-212

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Title

EFFECTS OF PORTULACA OLERACEA ETHANOLIC EXTRACT ON REPRODUCTIVE SYSTEM OF AGING FEMALE MICE

Author(s)

AHANGARPOUR AKRAM | LAMOOCHI ZOHREH | FATHI MOGHADDAM HADI | MANSOURI SEYED MOHAMMAD TAGHI | Issue Writer Certificate

Keywords

AGING

D-GALACTOSE

PORTULACA OLERACEA L (PURSLANE)

ANTIOXIDANT ENZYME

SEX HORMONES

Abstract

Background: AGING contains morphological and functional deterioration in biological systems. D-GALACTOSE (D-gal) generates free radicals and accelerates AGING. Portulaca oleracea (Purslane) may have protective effect against oxidative stress.Objective: Purslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in D-gal AGING female mice.Materials and Methods: 48 female NMRI mice (25-35 gr) were randomly divided into, 6 groups: 1- control (normal saline for 45 days), 2- Purslane (200 mg/kg for last 3 weeks), 3-D-gal (500 mg/kg for 45 days), 4-D-gal+Purslane, 5- AGING, 6-AGING+Purslane. SEX HORMONES, antioxidants and malondialdehyde (MDA) level of ovary and uterus were measured. Histological assessment was also done.Results: In D-gal treated and AGING animals, LH and FSH levels were significantly increased (p<0.001) while estrogen and progesterone levels were significantly reduced (p<0.001) in comparison with control group. MDA contents were significantly increased in ovaries and uterus of D-gal and AGING groups (p<0.01). Superoxide dismutase (SOD) (p<0.001) and catalase (p<0.01) activities were significantly decreased in both AGING and D-gal treated animals. Ovarian follicles were degenerated and atrophy on uterine wall and endometrial glands was observed in D-gal and AGING groups. Alteration in hormone levels, MDA contents and antioxidant activity were significantly reversed by Purslane (p<0.05). Purslane could also improve histological changes such as atrophy of endometrium.Conclusion: These findings indicate that Purslane can attenuate AGING alternations induced by D-gal and AGING in female reproductive system.

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APA: Copy

AHANGARPOUR, AKRAM, LAMOOCHI, ZOHREH, FATHI MOGHADDAM, HADI, & MANSOURI, SEYED MOHAMMAD TAGHI. (2016). EFFECTS OF PORTULACA OLERACEA ETHANOLIC EXTRACT ON REPRODUCTIVE SYSTEM OF AGING FEMALE MICE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(3), 205-212. SID. https://sid.ir/paper/296245/en

Vancouver: Copy

AHANGARPOUR AKRAM, LAMOOCHI ZOHREH, FATHI MOGHADDAM HADI, MANSOURI SEYED MOHAMMAD TAGHI. EFFECTS OF PORTULACA OLERACEA ETHANOLIC EXTRACT ON REPRODUCTIVE SYSTEM OF AGING FEMALE MICE. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(3):205-212. Available from: https://sid.ir/paper/296245/en

IEEE: Copy

AKRAM AHANGARPOUR, ZOHREH LAMOOCHI, HADI FATHI MOGHADDAM, and SEYED MOHAMMAD TAGHI MANSOURI, “EFFECTS OF PORTULACA OLERACEA ETHANOLIC EXTRACT ON REPRODUCTIVE SYSTEM OF AGING FEMALE MICE,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 3, pp. 205–212, 2016, [Online]. Available: https://sid.ir/paper/296245/en

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