THE IL-6 -634C/G POLYMORPHISM: A CANDIDATE GENETIC MARKER FOR THE PREDICTION OF IDIOPATHIC RECURRENT PREGNANCY LOSS

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RASTI ZARNEGAR; NASIRI MAHBOOBEH; KOHAN LEILA

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Journal: International Journal of Reproductive BioMedicine Year:2016 | Volume:14 | Issue:2 Page(s): 103-108

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Title

THE IL-6 -634C/G POLYMORPHISM: A CANDIDATE GENETIC MARKER FOR THE PREDICTION OF IDIOPATHIC RECURRENT PREGNANCY LOSS

Author(s)

RASTI ZARNEGAR | NASIRI MAHBOOBEH | KOHAN LEILA | Issue Writer Certificate

Keywords

POLYMORPHISM

INTERLEUKIN-6

RECURRENT PREGNANCY LOSS

Abstract

Background: RECURRENT PREGNANCY LOSS (RPL) is defined as two or more miscarriages before the 20th week of gestation and its etiology is unknown in 50% of the cases. Interleukin 6 is an immune mediator, plays a regulatory role in embryo implantation and placental development.Objective: The purpose was to assess the association between IL-6 -634C/G POLYMORPHISM and, susceptibility to idiopathic RPL for the first time in Iran.Materials and Methods: In total 121 women with RPL and 121 healthy women as control group were enrolled in this case-control study. This study was performed from August 2013 to October 2014 in the Molecular Genetics Laboratory of Arsanjan University. Candidate POLYMORPHISM was evaluated by PCR-RFLP method on extracted genomic DNA. Data was analyzed using the statistical SPSS package.Results: Our results showed an increased risk of RPL in patients with GG+GC genotype (OR=5.1, 95%CI: 1.04-25.3, p=0.04) in comparison to CC genotype. The frequency of mutant allele G in patients and controls was 0.75 and 0.66 respectively. The mutant allele G predisposes women to miscarriage 1.5 times greater than controls (OR=1.5, 95%CI: 1.03-2.27, p=0.036). The mean number of live births in RPL women (1.3±2.3) was significantly lower compared to control women (4.8±2.3).Conclusion: This study indicated that the promoter POLYMORPHISM (-634C/G) of the IL-6 gene has likely influence on individual susceptibility to RPL.

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APA: Copy

RASTI, ZARNEGAR, NASIRI, MAHBOOBEH, & KOHAN, LEILA. (2016). THE IL-6 -634C/G POLYMORPHISM: A CANDIDATE GENETIC MARKER FOR THE PREDICTION OF IDIOPATHIC RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), 14(2), 103-108. SID. https://sid.ir/paper/296250/en

Vancouver: Copy

RASTI ZARNEGAR, NASIRI MAHBOOBEH, KOHAN LEILA. THE IL-6 -634C/G POLYMORPHISM: A CANDIDATE GENETIC MARKER FOR THE PREDICTION OF IDIOPATHIC RECURRENT PREGNANCY LOSS. INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE)[Internet]. 2016;14(2):103-108. Available from: https://sid.ir/paper/296250/en

IEEE: Copy

ZARNEGAR RASTI, MAHBOOBEH NASIRI, and LEILA KOHAN, “THE IL-6 -634C/G POLYMORPHISM: A CANDIDATE GENETIC MARKER FOR THE PREDICTION OF IDIOPATHIC RECURRENT PREGNANCY LOSS,” INTERNATIONAL JOURNAL OF REPRODUCTIVE BIOMEDICINE (IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE), vol. 14, no. 2, pp. 103–108, 2016, [Online]. Available: https://sid.ir/paper/296250/en

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